ID   B4E298_HUMAN            Unreviewed;       158 AA.
AC   B4E298;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   12-SEP-2018, entry version 60.
DE   SubName: Full=Methyltransferase like 17 isoform 2 {ECO:0000313|EMBL:ALQ34206.1};
DE   SubName: Full=Methyltransferase-like protein 17, mitochondrial {ECO:0000313|Ensembl:ENSP00000450782};
DE   SubName: Full=cDNA FLJ55011, highly similar to Homo sapiens methyltransferase 11 domain containing 1 isoform 3 {ECO:0000313|EMBL:BAG65060.1};
DE   SubName: Full=cDNA, FLJ78898, highly similar to Homo sapiens methyltransferase 11 domain containing 1 isoform 3 {ECO:0000313|EMBL:BAH14370.1};
GN   Name=METTL17 {ECO:0000313|EMBL:ALQ34206.1,
GN   ECO:0000313|Ensembl:ENSP00000450782};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG65060.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000450782, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|EMBL:BAG65060.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Trachea {ECO:0000313|EMBL:BAG65060.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:BAH14370.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAH14370.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000450782}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [5] {ECO:0000313|EMBL:ALQ34206.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26871637; DOI=10.1016/j.cell.2016.01.029;
RA   Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T.,
RA   Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K.,
RA   Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q.,
RA   Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D.,
RA   Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J.,
RA   Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P.,
RA   Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.;
RT   "Widespread Expansion of Protein Interaction Capabilities by
RT   Alternative Splicing.";
RL   Cell 164:805-817(2016).
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DR   EMBL; AL355922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KU178748; ALQ34206.1; -; mRNA.
DR   EMBL; AK304180; BAG65060.1; -; mRNA.
DR   EMBL; AK315999; BAH14370.1; -; mRNA.
DR   UniGene; Hs.512693; -.
DR   MaxQB; B4E298; -.
DR   PeptideAtlas; B4E298; -.
DR   PRIDE; B4E298; -.
DR   Ensembl; ENST00000555533; ENSP00000450948; ENSG00000165792.
DR   Ensembl; ENST00000555640; ENSP00000450782; ENSG00000165792.
DR   Ensembl; ENST00000557550; ENSP00000452392; ENSG00000165792.
DR   UCSC; uc058yvm.1; human.
DR   EuPathDB; HostDB:ENSG00000165792.17; -.
DR   HGNC; HGNC:19280; METTL17.
DR   OpenTargets; ENSG00000165792; -.
DR   eggNOG; KOG2539; Eukaryota.
DR   eggNOG; COG5459; LUCA.
DR   GeneTree; ENSGT00390000006103; -.
DR   ChiTaRS; METTL17; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000165792; Expressed in 212 organ(s), highest expression level in left lobe of thyroid gland.
DR   ExpressionAtlas; B4E298; baseline and differential.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Methyltransferase {ECO:0000313|EMBL:BAG65060.1};
KW   Proteomics identification {ECO:0000213|EPD:B4E298,
KW   ECO:0000213|PeptideAtlas:B4E298};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:BAG65060.1}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    158       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085118.
SQ   SEQUENCE   158 AA;  17748 MW;  D7D31D6A4B4D3593 CRC64;
     MAAALKCLLT LGRWCPGLGV APQARALAAL VPGVTQVDNK SGFLQKRPHR QHPGILKLPH
     VRLPQALANG AQLLLLGSAG PTMENQVQTL TSYLWSRHLP VEPEELQRRA RHLEKKFLEN
     PGPDFQSLFS PQTYLRQRRN FVEQCYTHYV KLPTIGKN
//