ID   B4E1Z4_HUMAN            Unreviewed;      1266 AA.
AC   B4E1Z4;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   13-FEB-2019, entry version 103.
DE   SubName: Full=cDNA FLJ55673, highly similar to Complement factor B {ECO:0000313|EMBL:BAG64956.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64956.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000410815, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:BAG64956.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Trachea {ECO:0000313|EMBL:BAG64956.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000410815}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL645922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK304045; BAG64956.1; -; mRNA.
DR   SMR; B4E1Z4; -.
DR   STRING; 9606.ENSP00000410815; -.
DR   BioMuta; ENSG00000244255; -.
DR   jPOST; B4E1Z4; -.
DR   MaxQB; B4E1Z4; -.
DR   PRIDE; B4E1Z4; -.
DR   Ensembl; ENST00000456570; ENSP00000410815; ENSG00000244255.
DR   UCSC; uc011dor.4; human.
DR   EuPathDB; HostDB:ENSG00000244255.5; -.
DR   GeneCards; ENSG00000244255; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000158605; -.
DR   HOGENOM; HOG000038034; -.
DR   HOVERGEN; HBG106859; -.
DR   OMA; LSTTCQQ; -.
DR   TreeFam; TF330194; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000244255; Expressed in 67 organ(s), highest expression level in liver.
DR   ExpressionAtlas; B4E1Z4; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00033; CCP; 4.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.40.50.410; -; 2.
DR   InterPro; IPR028341; Complement_B.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR19325:SF394; PTHR19325:SF394; 4.
DR   Pfam; PF00084; Sushi; 4.
DR   Pfam; PF00089; Trypsin; 2.
DR   Pfam; PF00092; VWA; 2.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00032; CCP; 5.
DR   SMART; SM00020; Tryp_SPc; 2.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF50494; SSF50494; 2.
DR   SUPFAM; SSF53300; SSF53300; 2.
DR   SUPFAM; SSF57535; SSF57535; 5.
DR   PROSITE; PS50923; SUSHI; 5.
DR   PROSITE; PS50240; TRYPSIN_DOM; 2.
DR   PROSITE; PS00134; TRYPSIN_HIS; 2.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
DR   PROSITE; PS50234; VWFA; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B4E1Z4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1266       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014567695.
FT   DOMAIN       22     86       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN       87    144       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      173    299       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      311    590       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DOMAIN      537    602       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      603    662       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      665    722       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      772    971       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      979   1259       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DISULFID    115    142       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    633    660       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    693    720       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   1266 AA;  140943 MW;  89105C1F976EB53D CRC64;
     MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS CPQGLYPSPA
     SRLCKSSGQW QTPGATRSLS KAVCKPGHCP NPGISLGAVR TGFRFGHGDK VRYRCSSNLV
     LTGSSERECQ GNGVWSGTEP ICRQPYSYDF PEDVAPALGT SFSHMLGATN PTQKTKDHEN
     GTGTNTYAAL NSVYLMMNNQ MRLLGMETMA WQEIRHAIIL LTDGKSNMGG SPKTAVDHIR
     EILNINQKRN DYLDIYAIGV GKLDVDWREL NELGSKKDGE RHAFILQDTK ALHQVFEHML
     DVSKLTDTIC GVGNMSANAS DQERTPWHVT IKPKSQETCR GALISDQWVL TAAHCFRDGN
     DHSLWRVNVG DPKSQWGKEF LIEKAVISPG FDVFAKKNQG ILEFYGDDIA LLKLAQKVKM
     STHARPICLP CTMEANLALR RPQGSTCRDH ENELLNKQSV PAHFVALNGS KLNINLKMGV
     EWTSCAEVVS QEKTMFPNLT DVREVVTDQF LCSGTQEDES PCKGVTTTPW SLARPQGSCS
     LEGVEIKGGS FRLLQEGQAL EYVCPSGFYP YPVQTRTCRS TGSWSTLKTQ DQKTVRKAEC
     RAIHCPRPHD FENGEYWPRS PYYNVSDEIS FHCYDGYTLR GSANRTCQVN GRWSGQTAIC
     DNGAGYCSNP GIPIGTRKVG SQYRLEDSVT YHCSRGLTLR GSQRRTCQEG GSWSGTEPSC
     QDSFMYDTPQ EVAEAFLSSL TETIEGVDAE DGHGPGEQQK RKIVLDPSGS MNIYLVLDGS
     DSIGASNFTG AKKCLVNLIE KVASYGVKPR YGLVTYATYP KIWVKVSEAD SSNADWVTKQ
     LNEINYEDHK LKSGTNTKKA LQAVYSMMSW PDDVPPEGWN RTRHVIILMT DGLHNMGGDP
     ITVIDEIRDL LYIGKDRKNP REDYLDVYVF GVGPLVNQVN INALASKKDN EQHVFKVKDM
     ENLEDVFYQM IDESQSLSLC GMVWEHRKGT DYHKQPWQAK ISVIRPSKGH ESCMGAVVSE
     YFVLTAAHCF TVDDKEHSIK VSVGGEKRDL EIEVVLFHPN YNINGKKEAG IPEFYDYDVA
     LIKLKNKLKY GQTIRPICLP CTEGTTRALR LPPTTTCQQQ KEELLPAQDI KALFVSEEEK
     KLTRKEVYIK NGDKKGSCER DAQYAPGYDK VKDISEVVTP RFLCTGGVSP YADPNTCRGD
     SGGPLIVHKR SRFIQVGVIS WGVVDVCKNQ KRQKQVPAHA RDFHINLFQV LPWLKEKLQD
     EDLGFL
//