ID   B4DWY7_HUMAN            Unreviewed;       672 AA.
AC   B4DWY7;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 92.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 2 {ECO:0000313|Ensembl:ENSP00000429352};
DE   SubName: Full=cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2) {ECO:0000313|EMBL:BAG63199.1};
GN   Name=ADAM2 {ECO:0000313|Ensembl:ENSP00000429352};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63199.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429352, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|EMBL:BAG63199.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAG63199.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000429352}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000483607}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [5] {ECO:0000313|Ensembl:ENSP00000478636}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [6] {ECO:0000313|Ensembl:ENSP00000488853}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   EMBL; AC136365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC244257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP005902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK301734; BAG63199.1; -; mRNA.
DR   RefSeq; NP_001265043.1; NM_001278114.1.
DR   UniGene; Hs.177959; -.
DR   PRIDE; B4DWY7; -.
DR   Ensembl; ENST00000521880; ENSP00000429352; ENSG00000104755.
DR   Ensembl; ENST00000611998; ENSP00000478636; ENSG00000276286.
DR   Ensembl; ENST00000622267; ENSP00000483607; ENSG00000104755.
DR   Ensembl; ENST00000633755; ENSP00000488853; ENSG00000276286.
DR   GeneID; 2515; -.
DR   UCSC; uc011lck.4; human.
DR   CTD; 2515; -.
DR   EuPathDB; HostDB:ENSG00000104755.14; -.
DR   HGNC; HGNC:198; ADAM2.
DR   OpenTargets; ENSG00000104755; -.
DR   GeneTree; ENSGT00940000161961; -.
DR   HOGENOM; HOG000230883; -.
DR   HOVERGEN; HBG103628; -.
DR   OrthoDB; 162519at2759; -.
DR   ChiTaRS; ADAM2; human.
DR   GenomeRNAi; 2515; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000104755; Expressed in 28 organ(s), highest expression level in testis.
DR   ExpressionAtlas; B4DWY7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR033958; ADAM2.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   PANTHER; PTHR11905:SF108; PTHR11905:SF108; 2.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00877335};
KW   Integrin {ECO:0000313|EMBL:BAG63199.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B4DWY7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    672       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014567691.
FT   TRANSMEM    624    644       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      178    375       Peptidase M12B.
FT                                {ECO:0000259|PROSITE:PS50215}.
FT   DOMAIN      384    473       Disintegrin.
FT                                {ECO:0000259|PROSITE:PS50214}.
FT   DISULFID    445    465       {ECO:0000256|PROSITE-ProRule:PRU00068}.
SQ   SEQUENCE   672 AA;  75588 MW;  251DEC8937B5504E CRC64;
     MWRVLFLLSG LGGLRMDSNF DSLPVQITVP EKIRSIIKEG IESQASYKIV IEGKPYTVNL
     MQKNFLPHNF RVYSYSGTGI MKPLDQDFQN FCHYQGYIEG YPKSVVMVST CTGLRGVLQF
     ENVSYGIEPL ESSVGFEHVI YQVKHKKADV SLYNEKDIES RDLSFKLQSV EPQQDFAKYI
     EMHVIVEKQL YNHMGSDTTV VAQKVFQLIG LTNAIFVSFN ITIILSSLEL WIDENKIATT
     GEANELLHTF LRWKTSYLVL RPHDVAFLLV YREKSNYVGA TFQGKMCDAN YAGGVVLHPR
     TISLESLAVI LAQLLSLSMG ITYDDINKCQ CSGAVCIMNP EAIHFSGVKI FSNCSFEDFA
     HFISKQKSQC LHNQPRLDPF FKQQAVCGNA KLEAGEECDC GTEQDCALIG ETCCDIATCR
     FKAGSNCAEG PCCENCLFMS KERMCRPSFE ECDLPEYCNG SSASCPENHY VQTGHPCGLN
     QWICIDGVCM SGDKQCTDTF GKEVEFGPSE CYSHLNSKTD VSGNCGISDS GYTQCEVCRN
     QRCVSSSYLG YDCTTDKCND RGVCNNKKHC HCSASYLPPD CSVQSDLWPG GSIDSGNFPP
     VAIPARLPER RYIENIYHSK PMRWPFFLFI PFFIIFCVLI AIMVKVNFQR KKWRTEDYSS
     DEQPESESEP KG
//