ID B4DWB8_HUMAN Unreviewed; 379 AA. AC B4DWB8; E9PEL8; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 16-JAN-2019, entry version 88. DE SubName: Full=Adhesion G protein-coupled receptor E2 {ECO:0000313|Ensembl:ENSP00000376689}; DE SubName: Full=cDNA FLJ60183, highly similar to Homo sapiens egf-like module containing, mucin-like, hormone receptor-like 2, transcript variant 6, mRNA {ECO:0000313|EMBL:BAG62980.1}; GN Name=ADGRE2 {ECO:0000313|Ensembl:ENSP00000376689}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62980.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000376689, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|EMBL:BAG62980.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Synovial membrane tissue {ECO:0000313|EMBL:BAG62980.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000376689} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090427; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK301458; BAG62980.1; -; mRNA. DR UniGene; Hs.531619; -. DR jPOST; B4DWB8; -. DR MaxQB; B4DWB8; -. DR PeptideAtlas; B4DWB8; -. DR PRIDE; B4DWB8; -. DR Ensembl; ENST00000392962; ENSP00000376689; ENSG00000127507. DR UCSC; uc060uqx.1; human. DR EuPathDB; HostDB:ENSG00000127507.17; -. DR HGNC; HGNC:3337; ADGRE2. DR OpenTargets; ENSG00000127507; -. DR GeneTree; ENSGT00940000162597; -. DR HOGENOM; HOG000294115; -. DR HOVERGEN; HBG103569; -. DR ChiTaRS; ADGRE2; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000127507; Expressed in 120 organ(s), highest expression level in blood. DR ExpressionAtlas; B4DWB8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR003056; GPCR_2_CD97. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR Pfam; PF07645; EGF_CA; 3. DR PRINTS; PR01278; CD97PROTEIN. DR SMART; SM00181; EGF; 4. DR SMART; SM00179; EGF_CA; 3. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS50026; EGF_3; 3. DR PROSITE; PS01187; EGF_CA; 2. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00909960}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|MaxQB:B4DWB8, KW ECO:0000213|PeptideAtlas:B4DWB8}; KW Receptor {ECO:0000313|EMBL:BAG62980.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 379 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014085108. FT DOMAIN 67 106 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 119 162 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 163 201 EGF-like. {ECO:0000259|PROSITE:PS50026}. SQ SEQUENCE 379 AA; 41390 MW; B696672796F2B7CF CRC64; MGGRVFLVFL AFCVWLTLPG AETQDSRGCA RWCPQDSSCV NATACRCNPG FSSFSEIITT PMETCDDINE CATLSKVSCG KFSDCWNTEG SYDCVCSPGY EPVSGAKTFK NESENTCQDV DECQQNPRLC KSYGTCVNTL GSYTCQCLPG FKLKPEDPKL CTDVDECSSG QHQCDSSTVC FNTVGSYSCR CRPGWKPRHG IPNNQKDTVC EDMTFSTWTP PPGVHSQTLS RFFDKVQDLG RDYKPGLANN TIQSILQALD ELLEAPGDLE TLPRLQQHCV ASHLLDGLED VLRGLSKNLS NGLLNFSYPA GTELSLEVQK QVDRSVTLRQ NQAVMQLDWN QAQKSGDPGG GSRADCHHLH GAERLSAVPP PGGPHFSPV //