ID   B4DTR8_HUMAN            Unreviewed;       426 AA.
AC   B4DTR8;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 89.
DE   SubName: Full=Endothelial lipase {ECO:0000313|Ensembl:ENSP00000387978};
DE   SubName: Full=cDNA FLJ57818, highly similar to Endothelial lipase {ECO:0000313|EMBL:BAG62080.1};
GN   Name=LIPG {ECO:0000313|Ensembl:ENSP00000387978};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62080.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387978, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|EMBL:BAG62080.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Placenta {ECO:0000313|EMBL:BAG62080.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000387978}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; AC091170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK300333; BAG62080.1; -; mRNA.
DR   RefSeq; NP_001294935.1; NM_001308006.1.
DR   UniGene; Hs.465102; -.
DR   ESTHER; human-LIPG; Lipoprotein_Lipase.
DR   MaxQB; B4DTR8; -.
DR   PRIDE; B4DTR8; -.
DR   Ensembl; ENST00000427224; ENSP00000387978; ENSG00000101670.
DR   GeneID; 9388; -.
DR   UCSC; uc010xdh.3; human.
DR   CTD; 9388; -.
DR   EuPathDB; HostDB:ENSG00000101670.11; -.
DR   HGNC; HGNC:6623; LIPG.
DR   OpenTargets; ENSG00000101670; -.
DR   GeneTree; ENSGT00940000159394; -.
DR   HOVERGEN; HBG002259; -.
DR   OrthoDB; 534956at2759; -.
DR   ChiTaRS; LIPG; human.
DR   GenomeRNAi; 9388; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000101670; Expressed in 142 organ(s), highest expression level in left lobe of thyroid gland.
DR   ExpressionAtlas; B4DTR8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004465; F:lipoprotein lipase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR002330; Lipo_Lipase.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 2.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 2.
DR   PRINTS; PR00822; LIPOLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B4DTR8,
KW   ECO:0000213|PeptideAtlas:B4DTR8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    426       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085114.
FT   DOMAIN      273    408       PLAT. {ECO:0000259|PROSITE:PS50095}.
SQ   SEQUENCE   426 AA;  48963 MW;  67509F7EC1BE4793 CRC64;
     MSNSVPLLCF WSLCYCFAAG SPVPFGPEGR LEDKLHKPKA TQTEVKPSVR FNLRTSKDPE
     HEGCYLSVGH SQPLEDCSFN MTAKTFFIIH GWTMSGIFEN WLHKLVSALH TREKDANVVV
     VDWLPLAHQL YTDAVNNTRV VGHSIARMLD WLQEKDDFSL GNVHLIGYSL GAHVAGYAGN
     FVKGTVGRIT AITEVVKCEH ERAVHLFVDS LVNQDKPSFA FQCTDSNRFK KGICLSCRKN
     RCNSIGYNAK KMRNKRNSKM YLKTRAGMPF RVYHYQMKIH VFSYKNMGEI EPTFYVTLYG
     TNADSQTLPL EIVERIEQNA TNTFLVYTEE DLGDLLKIQL TWEGASQSWY NLWKEFRSYL
     SQPRNPGREL NIRRIRVKSG ETQRKLTFCT EDPENTSISP GRELWFRKCR DGWRMKNETS
     PTVELP
//