ID   SHSA9_HUMAN             Reviewed;         424 AA.
AC   B4DS77; C9J314; C9JCE9;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   13-FEB-2019, entry version 78.
DE   RecName: Full=Protein shisa-9;
DE   Flags: Precursor;
GN   Name=SHISA9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in
CC       the dentate gyrus. Associates with AMPA receptors (ionotropic
CC       glutamate receptors) in synaptic spines and promotes AMPA receptor
CC       desensitization at excitatory synapses (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of some AMPA receptors (ionotropic glutamate
CC       receptors) complex, at least composed of some AMPA receptor
CC       (GRIA1, GRIA2 and/or GRIA3), CACNG2 and SHISA9, as well as low
CC       level of DLG4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Cell junction, synapse {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=B4DS77-1; Sequence=Displayed;
CC         Note=No experimental confirmation available.;
CC       Name=2;
CC         IsoId=B4DS77-2; Sequence=VSP_038817;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=B4DS77-3; Sequence=VSP_038818, VSP_038819;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AK299610; BAG61539.1; -; mRNA.
DR   EMBL; AC009134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45417.2; -. [B4DS77-1]
DR   CCDS; CCDS45418.2; -. [B4DS77-3]
DR   RefSeq; NP_001138676.2; NM_001145204.2. [B4DS77-1]
DR   RefSeq; NP_001138677.2; NM_001145205.1. [B4DS77-3]
DR   UniGene; Hs.130661; -.
DR   ProteinModelPortal; B4DS77; -.
DR   SMR; B4DS77; -.
DR   BioGrid; 610383; 1.
DR   IntAct; B4DS77; 1.
DR   STRING; 9606.ENSP00000454014; -.
DR   TCDB; 8.A.83.1.3; the shisa6 regulator of short-term neuronal synaptic plasticity (shisa) family.
DR   iPTMnet; B4DS77; -.
DR   PhosphoSitePlus; B4DS77; -.
DR   BioMuta; SHISA9; -.
DR   PaxDb; B4DS77; -.
DR   PRIDE; B4DS77; -.
DR   ProteomicsDB; 5005; -.
DR   ProteomicsDB; 5006; -. [B4DS77-2]
DR   ProteomicsDB; 5007; -. [B4DS77-3]
DR   Ensembl; ENST00000423335; ENSP00000395245; ENSG00000237515. [B4DS77-3]
DR   Ensembl; ENST00000558583; ENSP00000454014; ENSG00000237515. [B4DS77-1]
DR   GeneID; 729993; -.
DR   KEGG; hsa:729993; -.
DR   UCSC; uc002dcd.3; human. [B4DS77-1]
DR   CTD; 729993; -.
DR   DisGeNET; 729993; -.
DR   EuPathDB; HostDB:ENSG00000237515.7; -.
DR   GeneCards; SHISA9; -.
DR   HGNC; HGNC:37231; SHISA9.
DR   MIM; 613346; gene.
DR   neXtProt; NX_B4DS77; -.
DR   OpenTargets; ENSG00000237515; -.
DR   PharmGKB; PA165450677; -.
DR   eggNOG; ENOG410IK0B; Eukaryota.
DR   eggNOG; ENOG410YB4B; LUCA.
DR   GeneTree; ENSGT00940000161478; -.
DR   HOGENOM; HOG000169786; -.
DR   HOVERGEN; HBG055090; -.
DR   InParanoid; B4DS77; -.
DR   OMA; TGSYLYC; -.
DR   OrthoDB; 659452at2759; -.
DR   PhylomeDB; B4DS77; -.
DR   ChiTaRS; SHISA9; human.
DR   GenomeRNAi; 729993; -.
DR   PRO; PR:B4DS77; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000237515; Expressed in 101 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; B4DS77; baseline and differential.
DR   Genevisible; B4DS77; HS.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0032591; C:dendritic spine membrane; ISS:UniProtKB.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR   GO; GO:0008328; C:ionotropic glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; IEA:Ensembl.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; ISS:UniProtKB.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31774; PTHR31774; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell junction; Cell membrane; Cell projection;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Synapse; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    424       Protein shisa-9.
FT                                /FTId=PRO_0000392536.
FT   TOPO_DOM     24    149       Extracellular. {ECO:0000255}.
FT   TRANSMEM    150    170       Helical. {ECO:0000255}.
FT   TOPO_DOM    171    424       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     45     45       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     89     89       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    116    116       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ       1     80       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_038817.
FT   VAR_SEQ     189    221       ALADVMRPQGHCNTDHMERDLNIVVHVQHYENM -> LYDN
FT                                LLFMEAQISFQEDEPAPGEWSVGLQTWTV (in isoform
FT                                3). {ECO:0000305}.
FT                                /FTId=VSP_038818.
FT   VAR_SEQ     222    424       Missing (in isoform 3). {ECO:0000305}.
FT                                /FTId=VSP_038819.
SQ   SEQUENCE   424 AA;  46925 MW;  600FBCEB2846F615 CRC64;
     MRRVLRLLLG CFLTELCARV CRAQERAGHG QLAQLGGVLL LAGGNRSGAA SGEASEGAEA
     SDAPPTRAPT PDFCRGYFDV MGQWDPPFNC SSGDFIFCCG TCGFRFCCTF KKRRLNQSTC
     TNYDTPLWLN TGKPPARKDD PLHDPTKDKT NLIVYIICGV VAVMVLVGIF TKLGLEKAHR
     PQREHMSRAL ADVMRPQGHC NTDHMERDLN IVVHVQHYEN MDTRTPINNL HATQMNNAVP
     TSPLLQQMGH PHSYPNLGQI SNPYEQQPPG KELNKYASLK AVGSSDGDWA VSTLKSPKAD
     KVNDDFYTKR RHLAELAAKG NLPLHPVRVE DEPRAFSPEH GPAKQNGQKS RTNKMPPHPL
     AYTSTTNFKG WDPNEQSLRR QAYSNKGKLG TAETGSSDPL GTRPQHYPPP QPYFITNSKT
     EVTV
//