ID   B4DPQ0_HUMAN            Unreviewed;       719 AA.
AC   B4DPQ0; F5GZR1;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 97.
DE   SubName: Full=Complement C1r subcomponent {ECO:0000313|Ensembl:ENSP00000444271};
DE   SubName: Full=cDNA FLJ54471, highly similar to Complement C1r subcomponent {ECO:0000313|EMBL:BAG60662.1};
GN   Name=C1R {ECO:0000313|Ensembl:ENSP00000444271};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG60662.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000444271, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|EMBL:BAG60662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:BAG60662.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000444271}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00733161}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; ABBA01012193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABBA01017671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC233309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01126602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01126603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK298445; BAG60662.1; -; mRNA.
DR   RefSeq; XP_016875404.1; XM_017019915.1.
DR   UniGene; Hs.524224; -.
DR   UniGene; Hs.731679; -.
DR   jPOST; B4DPQ0; -.
DR   PRIDE; B4DPQ0; -.
DR   Ensembl; ENST00000536053; ENSP00000444271; ENSG00000159403.
DR   UCSC; uc010sfz.3; human.
DR   EuPathDB; HostDB:ENSG00000159403.15; -.
DR   HGNC; HGNC:1246; C1R.
DR   OpenTargets; ENSG00000159403; -.
DR   GeneTree; ENSGT00940000158621; -.
DR   HOGENOM; HOG000237311; -.
DR   HOVERGEN; HBG000559; -.
DR   OMA; FCGTQRP; -.
DR   ChiTaRS; C1R; human.
DR   GenomeRNAi; 715; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000159403; Expressed in 221 organ(s), highest expression level in liver.
DR   ExpressionAtlas; B4DPQ0; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro.
DR   CDD; cd00033; CCP; 2.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR035707; Complement_C1r.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR45206; PTHR45206; 1.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00084; Sushi; 2.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00032; CCP; 2.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00181; EGF; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   SUPFAM; SSF57535; SSF57535; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS50923; SUSHI; 2.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00731840};
KW   EGF-like domain {ECO:0000256|SAAS:SAAS00032677};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00802849};
KW   Protease {ECO:0000256|SAAS:SAAS00802849};
KW   Proteomics identification {ECO:0000213|MaxQB:B4DPQ0,
KW   ECO:0000213|PeptideAtlas:B4DPQ0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00887150};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00937752}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    719       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085097.
FT   DOMAIN       29    155       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      207    319       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      321    387       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      388    463       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      478    716       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DISULFID    207    234       {ECO:0000256|PROSITE-ProRule:PRU00059}.
SQ   SEQUENCE   719 AA;  81890 MW;  B4F7689720F6D15F CRC64;
     MSVRFRVGRE ENAQWWLLYL LVPALFCRAG GSIPIPQKLF GEVTSPLFPK PYPNNFETTT
     VITVPTGYRV KLVFQQFDLE PSEGCFYDYV KISADKKSLG RFCGQLGSPL GNPPGKKEFM
     SQGNKMLLTF HTDFSNEENG TIMFYKGFLA YYQAVDLDEC ASRSKSGEED PQPQCQHLCH
     NYVGGYFCSC RPGYELQEDR HSCQAECSSE LYTEASGYIS SLEYPRSYPP DLRCNYSIRV
     ERGLTLHLKF LEPFDIDDHQ QVHCPYDQLQ IYANGKNIGE FCGKQRPPDL DTSSNAVDLL
     FFTDESGDSR GWKLRYTTEI IKCPQPKTLD EFTIIQNLQP QYQFRDYFIA TCKQGYQLIE
     GNQVLHSFTA VCQDDGTWHR AMPRCKIKDC GQPRNLPNGD FRYTTTMGVN TYKARIQYYC
     HEPYYKMQTR AGSRESEQGV YTCTAQGIWK NEQKGEKIPR CLPVCGKPVN PVEQRQRIIG
     GQKAKMGNFP WQVFTNIHGR GGGALLGDRW ILTAAHTLYP KEHEAQSNAS LDVFLGHTNV
     EELMKLGNHP IRRVSVHPDY RQDESYNFEG DIALLELENS VTLGPNLLPI CLPDNDTFYD
     LGLMGYVSGF GVMEEKIAHD LRFVRLPVAN PQACENWLRG KNRMDVFSQN MFCAGHPSLK
     QDACQGDSGG VFAVRDPNTD RWVATGIVSW GIGCSRGYGF YTKVLNYVDW IKKEMEEED
//