ID B4DNJ1_HUMAN Unreviewed; 436 AA. AC B4DNJ1; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 16-JAN-2019, entry version 99. DE SubName: Full=Tissue-type plasminogen activator {ECO:0000313|Ensembl:ENSP00000407861}; DE SubName: Full=cDNA FLJ59358, highly similar to Tissue-type plasminogen activator {ECO:0000313|EMBL:BAG60253.1}; GN Name=PLAT {ECO:0000313|Ensembl:ENSP00000407861}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG60253.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000407861, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000313|EMBL:BAG60253.1} RP NUCLEOTIDE SEQUENCE. RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000407861} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the peptidase S1 family. CC {ECO:0000256|SAAS:SAAS00559343}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC083973; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC103724; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK297937; BAG60253.1; -; mRNA. DR UniGene; Hs.491582; -. DR jPOST; B4DNJ1; -. DR MaxQB; B4DNJ1; -. DR PRIDE; B4DNJ1; -. DR Ensembl; ENST00000429710; ENSP00000407861; ENSG00000104368. DR UCSC; uc011lcn.2; human. DR EuPathDB; HostDB:ENSG00000104368.17; -. DR HGNC; HGNC:9051; PLAT. DR OpenTargets; ENSG00000104368; -. DR eggNOG; KOG3627; Eukaryota. DR eggNOG; COG5640; LUCA. DR GeneTree; ENSGT00940000158930; -. DR HOGENOM; HOG000237314; -. DR HOVERGEN; HBG008633; -. DR ChiTaRS; PLAT; human. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000104368; Expressed in 217 organ(s), highest expression level in metanephric glomerulus. DR ExpressionAtlas; B4DNJ1; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0031639; P:plasminogen activation; IEA:InterPro. DR CDD; cd00061; FN1; 1. DR CDD; cd00108; KR; 1. DR CDD; cd00190; Tryp_SPc; 1. DR Gene3D; 2.40.20.10; -; 1. DR InterPro; IPR000083; Fibronectin_type1. DR InterPro; IPR000001; Kringle. DR InterPro; IPR013806; Kringle-like. DR InterPro; IPR018056; Kringle_CS. DR InterPro; IPR038178; Kringle_sf. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR026280; Tissue_plasm_act. DR InterPro; IPR034811; tPA. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR InterPro; IPR033116; TRYPSIN_SER. DR PANTHER; PTHR44617; PTHR44617; 2. DR Pfam; PF00039; fn1; 1. DR Pfam; PF00051; Kringle; 1. DR Pfam; PF00089; Trypsin; 1. DR PIRSF; PIRSF001145; Tissue_plasm_act; 2. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00058; FN1; 1. DR SMART; SM00130; KR; 1. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR SUPFAM; SSF57440; SSF57440; 1. DR PROSITE; PS01253; FN1_1; 1. DR PROSITE; PS51091; FN1_2; 1. DR PROSITE; PS00021; KRINGLE_1; 1. DR PROSITE; PS50070; KRINGLE_2; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001145-3, KW ECO:0000256|SAAS:SAAS00037407}; KW Hydrolase {ECO:0000256|RuleBase:RU363034, KW ECO:0000256|SAAS:SAAS00745848}; KW Kringle {ECO:0000256|PROSITE-ProRule:PRU00121, KW ECO:0000256|SAAS:SAAS00045973}; KW Protease {ECO:0000256|RuleBase:RU363034, KW ECO:0000256|SAAS:SAAS00745848}; KW Proteomics identification {ECO:0000213|MaxQB:B4DNJ1, KW ECO:0000213|PeptideAtlas:B4DNJ1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Serine protease {ECO:0000256|RuleBase:RU363034, KW ECO:0000256|SAAS:SAAS00745848}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 436 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014567685. FT DOMAIN 39 81 Fibronectin type-I. FT {ECO:0000259|PROSITE:PS51091}. FT DOMAIN 88 170 Kringle. {ECO:0000259|PROSITE:PS50070}. FT DOMAIN 185 435 Peptidase S1. FT {ECO:0000259|PROSITE:PS50240}. FT ACT_SITE 231 231 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR001145-1}. FT ACT_SITE 280 280 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR001145-1}. FT ACT_SITE 387 387 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR001145-1}. FT DISULFID 89 170 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 110 152 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 141 165 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 173 304 Interchain (between A and B chains). FT {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 216 232 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 224 293 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 318 393 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 350 366 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 383 411 {ECO:0000256|PIRSR:PIRSR001145-3}. SQ SEQUENCE 436 AA; 49080 MW; 3B61FE55E84C156D CRC64; MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKRNSDCY FGNGSAYRGT HSLTESGASC LPWNSMILIG KVYTAQNPSA QALGLGKHNY CRNPDGDAKP WCHVLKNRRL TWEYCDVPSC STCGLRQYSQ PQFRIKGGLF ADIASHPWQA AIFAKHRRSP GERFLCGGIL ISSCWILSAA HCFQERFPPH HLTVILGRTY RVVPGEEEQK FEVEKYIVHK EFDDDTYDND IALLQLKSDS SRCAQESSVV RTVCLPPADL QLPDWTECEL SGYGKHEALS PFYSERLKEA HVRLYPSSRC TSQHLLNRTV TDNMLCAGDT RSGGPQANLH DACQGDSGGP LVCLNDGRMT LVGIISWGLG CGQKDVPGVY TKVTNYLDWI RDNMRP //