ID B4DN26_HUMAN Unreviewed; 473 AA. AC B4DN26; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 16-JAN-2019, entry version 103. DE SubName: Full=Tissue-type plasminogen activator {ECO:0000313|Ensembl:ENSP00000429401}; DE SubName: Full=cDNA FLJ59355, highly similar to Tissue-type plasminogen activator {ECO:0000313|EMBL:BAG60088.1}; GN Name=PLAT {ECO:0000313|Ensembl:ENSP00000429401}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG60088.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000429401, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000313|EMBL:BAG60088.1} RP NUCLEOTIDE SEQUENCE. RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000429401} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00748227}. CC -!- SIMILARITY: Belongs to the peptidase S1 family. CC {ECO:0000256|SAAS:SAAS00559343}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC083973; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC103724; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK297738; BAG60088.1; -; mRNA. DR RefSeq; NP_001306118.1; NM_001319189.1. DR UniGene; Hs.491582; -. DR jPOST; B4DN26; -. DR MaxQB; B4DN26; -. DR PRIDE; B4DN26; -. DR Ensembl; ENST00000524009; ENSP00000429401; ENSG00000104368. DR GeneID; 5327; -. DR UCSC; uc011lcm.2; human. DR CTD; 5327; -. DR EuPathDB; HostDB:ENSG00000104368.17; -. DR HGNC; HGNC:9051; PLAT. DR OpenTargets; ENSG00000104368; -. DR GeneTree; ENSGT00940000158930; -. DR HOGENOM; HOG000237314; -. DR HOVERGEN; HBG008633; -. DR OrthoDB; 1314811at2759; -. DR ChiTaRS; PLAT; human. DR GenomeRNAi; 5327; -. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000104368; Expressed in 217 organ(s), highest expression level in metanephric glomerulus. DR ExpressionAtlas; B4DN26; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0031639; P:plasminogen activation; IEA:InterPro. DR CDD; cd00061; FN1; 1. DR CDD; cd00108; KR; 1. DR CDD; cd00190; Tryp_SPc; 1. DR Gene3D; 2.40.20.10; -; 1. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000083; Fibronectin_type1. DR InterPro; IPR000001; Kringle. DR InterPro; IPR013806; Kringle-like. DR InterPro; IPR018056; Kringle_CS. DR InterPro; IPR038178; Kringle_sf. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR026280; Tissue_plasm_act. DR InterPro; IPR034811; tPA. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR InterPro; IPR033116; TRYPSIN_SER. DR PANTHER; PTHR44617; PTHR44617; 2. DR Pfam; PF00008; EGF; 1. DR Pfam; PF00039; fn1; 1. DR Pfam; PF00051; Kringle; 1. DR Pfam; PF00089; Trypsin; 1. DR PIRSF; PIRSF001145; Tissue_plasm_act; 2. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00058; FN1; 1. DR SMART; SM00130; KR; 1. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR SUPFAM; SSF57440; SSF57440; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS01253; FN1_1; 1. DR PROSITE; PS51091; FN1_2; 1. DR PROSITE; PS00021; KRINGLE_1; 1. DR PROSITE; PS50070; KRINGLE_2; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001145-3, ECO:0000256|PROSITE- KW ProRule:PRU00076, ECO:0000256|SAAS:SAAS00037407}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00729996}; KW Hydrolase {ECO:0000256|RuleBase:RU363034, KW ECO:0000256|SAAS:SAAS00745848}; KW Kringle {ECO:0000256|PROSITE-ProRule:PRU00121, KW ECO:0000256|SAAS:SAAS00045973}; KW Protease {ECO:0000256|RuleBase:RU363034, KW ECO:0000256|SAAS:SAAS00745848}; KW Proteomics identification {ECO:0000213|MaxQB:B4DN26, KW ECO:0000213|PeptideAtlas:B4DN26}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|SAAS:SAAS00749664}; KW Serine protease {ECO:0000256|RuleBase:RU363034, KW ECO:0000256|SAAS:SAAS00745848}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 473 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014567682. FT DOMAIN 39 81 Fibronectin type-I. FT {ECO:0000259|PROSITE:PS51091}. FT DOMAIN 82 120 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 125 207 Kringle. {ECO:0000259|PROSITE:PS50070}. FT DOMAIN 222 472 Peptidase S1. FT {ECO:0000259|PROSITE:PS50240}. FT REGION 42 52 Important for binding to annexin A2. FT {ECO:0000256|PIRSR:PIRSR001145-2}. FT ACT_SITE 268 268 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR001145-1}. FT ACT_SITE 317 317 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR001145-1}. FT ACT_SITE 424 424 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR001145-1}. FT SITE 102 102 Important for binding to LRP1. FT {ECO:0000256|PIRSR:PIRSR001145-2}. FT SITE 375 375 Important for single-chain activity. FT {ECO:0000256|PIRSR:PIRSR001145-2}. FT SITE 423 423 Important for single-chain activity. FT {ECO:0000256|PIRSR:PIRSR001145-2}. FT DISULFID 41 71 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 69 78 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 86 97 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 91 108 {ECO:0000256|PIRSR:PIRSR001145-3, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 110 119 {ECO:0000256|PIRSR:PIRSR001145-3, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 126 207 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 147 189 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 178 202 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 210 341 Interchain (between A and B chains). FT {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 253 269 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 261 330 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 355 430 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 387 403 {ECO:0000256|PIRSR:PIRSR001145-3}. FT DISULFID 420 448 {ECO:0000256|PIRSR:PIRSR001145-3}. SQ SEQUENCE 473 AA; 52992 MW; AC4FB758DDF91A1D CRC64; MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE IGNSDCYFGN GSAYRGTHSL TESGASCLPW NSMILIGKVY TAQNPSAQAL GLGKHNYCRN PDGDAKPWCH VLKNRRLTWE YCDVPSCSTC GLRQYSQPQF RIKGGLFADI ASHPWQAAIF AKHRRSPGER FLCGGILISS CWILSAAHCF QERFPPHHLT VILGRTYRVV PGEEEQKFEV EKYIVHKEFD DDTYDNDIAL LQLKSDSSRC AQESSVVRTV CLPPADLQLP DWTECELSGY GKHEALSPFY SERLKEAHVR LYPSSRCTSQ HLLNRTVTDN MLCAGDTRSG GPQANLHDAC QGDSGGPLVC LNDGRMTLVG IISWGLGCGQ KDVPGVYTKV TNYLDWIRDN MRP //