ID   B4DIE3_HUMAN            Unreviewed;       197 AA.
AC   B4DIE3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 84.
DE   SubName: Full=Protein disulfide-isomerase TMX3 {ECO:0000313|Ensembl:ENSP00000402605};
DE   SubName: Full=cDNA FLJ60560, highly similar to Protein disulfide-isomerase TXNDC10 {ECO:0000313|EMBL:BAG58455.1};
GN   Name=TMX3 {ECO:0000313|Ensembl:ENSP00000402605};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG58455.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000402605, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|EMBL:BAG58455.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Hippocampus {ECO:0000313|EMBL:BAG58455.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000402605}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC040896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK295551; BAG58455.1; -; mRNA.
DR   UniGene; Hs.440534; -.
DR   SMR; B4DIE3; -.
DR   jPOST; B4DIE3; -.
DR   MaxQB; B4DIE3; -.
DR   PRIDE; B4DIE3; -.
DR   Ensembl; ENST00000443099; ENSP00000402605; ENSG00000166479.
DR   UCSC; uc010xfa.2; human.
DR   EuPathDB; HostDB:ENSG00000166479.9; -.
DR   HGNC; HGNC:24718; TMX3.
DR   OpenTargets; ENSG00000166479; -.
DR   GeneTree; ENSGT00930000151022; -.
DR   HOGENOM; HOG000207481; -.
DR   HOVERGEN; HBG102549; -.
DR   ChiTaRS; TMX3; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000166479; Expressed in 206 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; B4DIE3; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Isomerase {ECO:0000313|EMBL:BAG58455.1};
KW   Proteomics identification {ECO:0000213|EPD:B4DIE3,
KW   ECO:0000213|MaxQB:B4DIE3, ECO:0000213|PeptideAtlas:B4DIE3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    197       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085089.
FT   DOMAIN       10    149       Thioredoxin.
FT                                {ECO:0000259|PROSITE:PS51352}.
SQ   SEQUENCE   197 AA;  22670 MW;  45C2027D0A65506B CRC64;
     MAAWKSWTAL RLCATVVVLD MVVCKGFVED LDESFKENRN DDIWLVDFYA PWCGHCKKLE
     PIWNEVGLEM KSIGSPVKVG KMDATSYSSI ASEFGVRGYP TIKLALIRPL PSQQMFEHMQ
     KRHRVFFVYV GGESPLKEKY IDAASELIVY TYFFSASEEV VPEYVTLKEM PAVLVFKDET
     YFVYDGKFQI FNSCKTF
//