ID   B4DI92_HUMAN            Unreviewed;       147 AA.
AC   B4DI92;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   12-SEP-2018, entry version 56.
DE   SubName: Full=Sodium channel subunit beta-1 {ECO:0000313|Ensembl:ENSP00000468848};
DE   SubName: Full=cDNA FLJ55064, moderately similar to Sodium channel beta-1 subunit {ECO:0000313|EMBL:BAG58404.1};
GN   Name=SCN1B {ECO:0000313|Ensembl:ENSP00000468848};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG58404.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468848, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:BAG58404.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Hippocampus {ECO:0000313|EMBL:BAG58404.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000468848}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC020907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK295477; BAG58404.1; -; mRNA.
DR   UniGene; Hs.436646; -.
DR   SMR; B4DI92; -.
DR   PeptideAtlas; B4DI92; -.
DR   Ensembl; ENST00000595652; ENSP00000468848; ENSG00000105711.
DR   UCSC; uc010xsg.3; human.
DR   EuPathDB; HostDB:ENSG00000105711.10; -.
DR   HGNC; HGNC:10586; SCN1B.
DR   OpenTargets; ENSG00000105711; -.
DR   GeneTree; ENSGT00390000018560; -.
DR   HOVERGEN; HBG056582; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105711; Expressed in 86 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; B4DI92; baseline and differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   InterPro; IPR027098; Na_channel_b1/b3.
DR   PANTHER; PTHR10546; PTHR10546; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000313|EMBL:BAG58404.1};
KW   Ion transport {ECO:0000313|EMBL:BAG58404.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B4DI92};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000313|EMBL:BAG58404.1}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    147       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085092.
FT   TRANSMEM     90    111       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   147 AA;  16195 MW;  46E04D4A5BD030A7 CRC64;
     MGRLLALVVG AALVSSACGG CVEVDSETEA VYGMTFKILC ISCKRRSETN AETFTEWTFR
     QKGTEEFVKK IHIEVVDKAN RDMASIVSEI MMYVLIVVLT IWLVAEMIYC YKKIAAATET
     AAQENASEYL AITSESKENC TGVQVAE
//