ID   B4DGP2_HUMAN            Unreviewed;       784 AA.
AC   B4DGP2;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 84.
DE   SubName: Full=cDNA FLJ53318, highly similar to Relaxin receptor 1 {ECO:0000313|EMBL:BAG57853.1};
GN   Name=RXFP1 {ECO:0000313|Ensembl:ENSP00000405841};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57853.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000405841, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|EMBL:BAG57853.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAG57853.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000405841}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; AC019341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC121161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC125489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK294694; BAG57853.1; -; mRNA.
DR   RefSeq; NP_001240656.1; NM_001253727.1.
DR   UniGene; Hs.591686; -.
DR   PRIDE; B4DGP2; -.
DR   Ensembl; ENST00000423548; ENSP00000405841; ENSG00000171509.
DR   GeneID; 59350; -.
DR   UCSC; uc011cje.3; human.
DR   CTD; 59350; -.
DR   EuPathDB; HostDB:ENSG00000171509.15; -.
DR   HGNC; HGNC:19718; RXFP1.
DR   OpenTargets; ENSG00000171509; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; KOG2087; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000158241; -.
DR   HOGENOM; HOG000049056; -.
DR   HOVERGEN; HBG026354; -.
DR   OMA; HQFWYNY; -.
DR   OrthoDB; 559381at2759; -.
DR   GenomeRNAi; 59350; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000171509; Expressed in 94 organ(s), highest expression level in decidua.
DR   ExpressionAtlas; B4DGP2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0042562; F:hormone binding; IEA:Ensembl.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0060427; P:lung connective tissue development; IEA:Ensembl.
DR   GO; GO:0060658; P:nipple morphogenesis; IEA:Ensembl.
DR   GO; GO:0007567; P:parturition; IEA:Ensembl.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR008112; Relaxin_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01739; RELAXINR.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS51450; LRR; 10.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS01050632}; Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:BAG57853.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    784       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085090.
FT   TRANSMEM    437    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    467    491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    556    574       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    605    626       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    657    682       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    688    711       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      449    708       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
FT   DISULFID     47     62       {ECO:0000256|PROSITE-ProRule:PRU00124}.
SQ   SEQUENCE   784 AA;  90105 MW;  1E0472E5073694E9 CRC64;
     MTSGSVFFYI LIFGKYFSHG GGQDVKCSLG YFPCGNITKC LPQLLHCNGV DDCGNQADED
     NCGDNNGWSL QFDKYFASYY KMTSQYPFEA ETPECSFHFF LFITLLFLVP HCHHALPLPL
     DSVVGSVPVQ CLCQGLELDC DETNLRAVPS VSSNVTAMSL QWNLIRKLPP DCFKNYHDLQ
     KLYLQNNKIT SISIYAFRGL NSLTKLYLSH NRITFLKPGV FEDLHRLEWL IIEDNHLSRI
     SPPTFYGLNS LILLVLMNNV LTRLPDKPLC QHMPRLHWLD LEGNHIHNLR NLTFISCSNL
     TVLVMRKNKI NHLNENTFAP LQKLDELDLG SNKIENLPPL IFKDLKELSQ LNLSYNPIQK
     IQANQFDYLV KLKSLSLEGI EISNIQQRMF RPLMNLSHIY FKKFQYCGYA PHVRSCKPNT
     DGISSLENLL ASIIQRVFVW VVSAVTCFGN IFVICMRPYI RSENKLYAMS IISLCCADCL
     MGIYLFVIGG FDLKFRGEYN KHAQLWMEST HCQLVGSLAI LSTEVSVLLL TFLTLEKYIC
     IVYPFRCVRP GKCRTITVLI LIWITGFIVA FIPLSNKEFF KNYYGTNGVC FPLHSEDTES
     IGAQIYSVAI FLGINLAAFI IIVFSYGSMF YSVHQSAITA TEIRNQVKKE MILAKRFFFI
     VFTDALCWIP IFVVKFLSLL QVEIPGTITS WVVIFILPIN SALNPILYTL TTRPFKEMIH
     RFWYNYRQRK SMDSKGQKTY APSFIWVEMW PLQEMPPELM KPDLFTYPCE MSLISQSTRL
     NSYS
//