ID   B4DF51_HUMAN            Unreviewed;       212 AA.
AC   B4DF51;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 80.
DE   SubName: Full=cDNA FLJ50122, highly similar to Myeloid cell surface antigen CD33 {ECO:0000313|EMBL:BAG57312.1};
GN   Name=CD33 {ECO:0000313|Ensembl:ENSP00000403331};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57312.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000403331, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:BAG57312.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAG57312.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000403331}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC063977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK293934; BAG57312.1; -; mRNA.
DR   UniGene; Hs.83731; -.
DR   SMR; B4DF51; -.
DR   jPOST; B4DF51; -.
DR   PeptideAtlas; B4DF51; -.
DR   PRIDE; B4DF51; -.
DR   Ensembl; ENST00000436584; ENSP00000403331; ENSG00000105383.
DR   UCSC; uc061bwj.1; human.
DR   EuPathDB; HostDB:ENSG00000105383.14; -.
DR   HGNC; HGNC:1659; CD33.
DR   OpenTargets; ENSG00000105383; -.
DR   eggNOG; ENOG410IJT6; Eukaryota.
DR   eggNOG; ENOG410YKZU; LUCA.
DR   GeneTree; ENSGT00940000153250; -.
DR   HOGENOM; HOG000208462; -.
DR   HOVERGEN; HBG079399; -.
DR   ChiTaRS; CD33; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105383; Expressed in 116 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; B4DF51; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:B4DF51,
KW   ECO:0000213|MaxQB:B4DF51, ECO:0000213|PeptideAtlas:B4DF51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    212       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085091.
FT   TRANSMEM    134    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       18    101       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   212 AA;  22338 MW;  53F7EAF81451855D CRC64;
     MPLLLLLPLL WADLTHRPKI LIPGTLEPGH SKNLTCSVSW ACEQGTPPIF SWLSAAPTSL
     GPRTTHSSVL IITPRPQDHG TNLTCQVKFA GAGVTTERTI QLNVTYVPQN PTTGIFPGDG
     SGKQETRAGV VHGAIGGAGV TALLALCLCL IFFIVKTHRR KAARTAVGRN DTHPTTGSAS
     PVSDGASWHP VCPADTSSQC GPPSCPIQHF QN
//