ID   B3KV06_HUMAN            Unreviewed;       510 AA.
AC   B3KV06;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 93.
DE   SubName: Full=Matrix metalloproteinase-28 {ECO:0000313|Ensembl:ENSP00000481051};
DE   SubName: Full=cDNA FLJ16012 fis, clone NTONG2000413, highly similar to Matrix metalloproteinase-28 {ECO:0000313|EMBL:BAG53618.1};
GN   Name=MMP28 {ECO:0000313|Ensembl:ENSP00000481051};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG53618.1};
RN   [1] {ECO:0000313|EMBL:BAG53618.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Tongue {ECO:0000313|EMBL:BAG53618.1};
RA   Ninomiya K., Wagatsuma M., Kanda K., Kondo H., Yokoi T., Kodaira H.,
RA   Furuya T., Takahashi M., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Sugiyama T., Irie R.,
RA   Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA   Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H.,
RA   Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Murakawa K.,
RA   Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B.,
RA   Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSP00000481051, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3] {ECO:0000313|Ensembl:ENSP00000481051}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000488159}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS01067066};
CC   -!- SIMILARITY: Belongs to the peptidase M10A family.
CC       {ECO:0000256|SAAS:SAAS00542437}.
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DR   EMBL; AC006237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC015849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK122604; BAG53618.1; -; mRNA.
DR   RefSeq; NP_001027449.1; NM_001032278.2.
DR   RefSeq; NP_077278.1; NM_024302.4.
DR   RefSeq; NP_116568.1; NM_032950.3.
DR   UniGene; Hs.380710; -.
DR   Ensembl; ENST00000619655; ENSP00000481051; ENSG00000271447.
DR   Ensembl; ENST00000631999; ENSP00000488159; ENSG00000278843.
DR   GeneID; 79148; -.
DR   KEGG; hsa:79148; -.
DR   UCSC; uc032fbb.2; human.
DR   CTD; 79148; -.
DR   EuPathDB; HostDB:ENSG00000271447.5; -.
DR   HGNC; HGNC:14366; MMP28.
DR   OpenTargets; ENSG00000271447; -.
DR   eggNOG; KOG1565; Eukaryota.
DR   eggNOG; ENOG410XQ5D; LUCA.
DR   GeneTree; ENSGT00940000159596; -.
DR   HOVERGEN; HBG052484; -.
DR   KO; K08006; -.
DR   OrthoDB; 1075463at2759; -.
DR   GenomeRNAi; 79148; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000271447; Expressed in 187 organ(s), highest expression level in tibial nerve.
DR   ExpressionAtlas; B3KV06; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd04278; ZnMc_MMP; 1.
DR   Gene3D; 2.110.10.10; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR036375; Hemopexin-like_dom_sf.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   InterPro; IPR033739; M10A_MMP.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR028735; MMP28.
DR   InterPro; IPR001818; Pept_M10_metallopeptidase.
DR   InterPro; IPR021190; Pept_M10A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   PANTHER; PTHR10201:SF16; PTHR10201:SF16; 1.
DR   Pfam; PF00045; Hemopexin; 1.
DR   Pfam; PF00413; Peptidase_M10; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   PIRSF; PIRSF001191; Peptidase_M10A_matrix; 1.
DR   PRINTS; PR00138; MATRIXIN.
DR   SMART; SM00120; HX; 3.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50923; SSF50923; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00473618};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00973795};
KW   Metalloprotease {ECO:0000256|SAAS:SAAS00473618};
KW   Protease {ECO:0000256|SAAS:SAAS00473618};
KW   Proteomics identification {ECO:0000213|MaxQB:B3KV06,
KW   ECO:0000213|PeptideAtlas:B3KV06};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00710432};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|SAAS:SAAS00973802}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    510       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014085060.
FT   DOMAIN      126    285       ZnMc. {ECO:0000259|SMART:SM00235}.
FT   REPEAT      360    399       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
FT   REPEAT      405    453       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
FT   REPEAT      454    500       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
FT   ACT_SITE    241    241       {ECO:0000256|PIRSR:PIRSR001191-1}.
SQ   SEQUENCE   510 AA;  57619 MW;  B7B10788E2FB5410 CRC64;
     MVARVGLLLR ALQLLLWGHL DAQPAERGGQ ELRKEAEAFL EKYGYLNEQV PKAPTSTRFS
     DAIRAFQWVS QLPVSGVLDR ATLRQMTRPR CGVTDTNSYA AWAERISDLF ARHRTKMRRK
     KRFAKQGNKW YKQHLSYRLV NWPEHLPEPA VRGAVRAAFQ LWSNVSALEF WEAPATGPAD
     IRLTFFQGDH NDGLGNAFDG PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH
     EIGHTLGLTH SPAPRALMAP YYKRLGRDAL LSWDDVLAVQ SLYGKPLGGS VAVQLPGKLF
     TDFETWDSYS PQGRRPETQG PKYCHSSFDA ITVGSHFWEV AADGNVSEPR PLQERWVGLP
     PNIEAAAVSL NDGDFYFFKG GRCWRFRGPK PVWGLPQLCR AGGLPRHPDA ALFFPPLRRL
     ILFKGARYYV LARGGLQVEP YYPRSLQDWG GIPEEVSGAL PRPDGSIIFF RDDRYWRLDQ
     AKLQATTSGR WATELPWMGC WHANSGSALF
//