ID   PATE3_HUMAN             Reviewed;          98 AA.
AC   B3GLJ2; B5KFZ3;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Prostate and testis expressed protein 3;
DE   AltName: Full=Acrosomal vesicle protein HEL-127;
DE   AltName: Full=PATE-like protein DJ;
DE            Short=PATE-DJ;
DE   Flags: Precursor;
GN   Name=PATE3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=18387948; DOI=10.1074/jbc.M801454200;
RA   Levitin F., Weiss M., Hahn Y., Stern O., Papke R.L., Matusik R.,
RA   Nandana S.R., Ziv R., Pichinuk E., Salame S., Bera T., Vincent J.,
RA   Lee B., Pastan I., Wreschner D.H.;
RT   "PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins
RT   that are expressed in reproductive and neuron-rich tissues and possess
RT   neuromodulatory activity.";
RL   J. Biol. Chem. 283:16928-16939(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA   Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA   Jin S.H., Zhang Y.L.;
RT   "Transcriptome analysis of a cDNA library from adult human
RT   epididymis.";
RL   DNA Res. 15:115-122(2008).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in prostate and testis.
CC       {ECO:0000269|PubMed:18387948}.
CC   -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR   EMBL; EU703625; ACD81924.1; -; mRNA.
DR   EMBL; EF426753; ABR09862.1; -; mRNA.
DR   EMBL; AP003087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67664.1; -; Genomic_DNA.
DR   CCDS; CCDS44764.1; -.
DR   RefSeq; NP_001123355.3; NM_001129883.3.
DR   UniGene; Hs.131278; -.
DR   ProteinModelPortal; B3GLJ2; -.
DR   STRING; 9606.ENSP00000395505; -.
DR   iPTMnet; B3GLJ2; -.
DR   PhosphoSitePlus; B3GLJ2; -.
DR   BioMuta; PATE3; -.
DR   PaxDb; B3GLJ2; -.
DR   PRIDE; B3GLJ2; -.
DR   ProteomicsDB; 3478; -.
DR   Ensembl; ENST00000445202; ENSP00000395505; ENSG00000236027.
DR   GeneID; 100169851; -.
DR   KEGG; hsa:100169851; -.
DR   UCSC; uc009zbs.3; human.
DR   CTD; 100169851; -.
DR   EuPathDB; HostDB:ENSG00000236027.2; -.
DR   GeneCards; PATE3; -.
DR   H-InvDB; HIX0171300; -.
DR   HGNC; HGNC:35426; PATE3.
DR   neXtProt; NX_B3GLJ2; -.
DR   OpenTargets; ENSG00000236027; -.
DR   PharmGKB; PA164724396; -.
DR   eggNOG; ENOG410JEGC; Eukaryota.
DR   eggNOG; ENOG4111CEH; LUCA.
DR   GeneTree; ENSGT00690000102487; -.
DR   HOGENOM; HOG000115460; -.
DR   InParanoid; B3GLJ2; -.
DR   OMA; TCHLRTQ; -.
DR   OrthoDB; 1499349at2759; -.
DR   PhylomeDB; B3GLJ2; -.
DR   GenomeRNAi; 100169851; -.
DR   PRO; PR:B3GLJ2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000236027; Expressed in 7 organ(s), highest expression level in testis.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Polymorphism; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21     98       Prostate and testis expressed protein 3.
FT                                /FTId=PRO_0000354972.
FT   DOMAIN       21     97       UPAR/Ly6. {ECO:0000305}.
FT   DISULFID     23     50       {ECO:0000255}.
FT   DISULFID     26     35       {ECO:0000255}.
FT   DISULFID     42     68       {ECO:0000255}.
FT   DISULFID     72     88       {ECO:0000255}.
FT   VARIANT      30     30       T -> K (in dbSNP:rs1025165).
FT                                /FTId=VAR_059884.
FT   CONFLICT     58     58       R -> G (in Ref. 2; ABR09862).
FT                                {ECO:0000305}.
SQ   SEQUENCE   98 AA;  11747 MW;  322630EE4B301F8B CRC64;
     MNKHFLFLFL LYCLIVAVTS LQCITCHLRT RTDRCRRGFG VCTAQKGEAC MLLRIYQRNT
     LQISYMVCQK FCRDMTFDLR NRTYVHTCCN YNYCNFKL
//