ID   C1T9B_HUMAN             Reviewed;         333 AA.
AC   B2RNN3; A2A3T6; B9EH31; Q0VGC5; Q5VX65; Q5VX66; Q8IUU4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   16-JAN-2019, entry version 92.
DE   RecName: Full=Complement C1q and tumor necrosis factor-related protein 9B;
DE   AltName: Full=C1q/TNF-related protein 9B;
DE            Short=CTRP9B;
DE   AltName: Full=Complement C1q and tumor necrosis factor-related protein 9-like;
DE   Flags: Precursor;
GN   Name=C1QTNF9B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Hippocampus;
RX   PubMed=19666007; DOI=10.1016/j.bbrc.2009.08.014;
RA   Peterson J.M., Wei Z., Wong G.W.;
RT   "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with
RT   C1q/TNF family members.";
RL   Biochem. Biophys. Res. Commun. 388:360-365(2009).
CC   -!- FUNCTION: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK
CC       signaling pathways. {ECO:0000250|UniProtKB:Q4ZJN1}.
CC   -!- SUBUNIT: Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and
CC       heterooligomeric complexes with CTRP9A.
CC       {ECO:0000269|PubMed:19666007}.
CC   -!- INTERACTION:
CC       P0C862:C1QTNF9; NbExp=2; IntAct=EBI-10828035, EBI-5654640;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19666007}.
CC       Note=Heteromeric complex formation with CTRP9A or ADIPOQ is
CC       required for secretion, otherwise, it is retained in the
CC       endoplasmic reticulum.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B2RNN3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B2RNN3-2; Sequence=VSP_035153, VSP_035154;
CC   -!- TISSUE SPECIFICITY: Expressed at low levels. Not expressed in
CC       adipose tissues. {ECO:0000269|PubMed:19666007}.
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DR   EMBL; AL445985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC110413; AAI10414.1; -; mRNA.
DR   EMBL; BC137004; AAI37005.1; -; mRNA.
DR   EMBL; BC137006; AAI37007.1; -; mRNA.
DR   CCDS; CCDS31947.1; -. [B2RNN3-1]
DR   RefSeq; NP_001007538.1; NM_001007537.2. [B2RNN3-1]
DR   RefSeq; XP_011533372.1; XM_011535070.2.
DR   UniGene; Hs.740810; -.
DR   ProteinModelPortal; B2RNN3; -.
DR   SMR; B2RNN3; -.
DR   BioGrid; 132501; 23.
DR   IntAct; B2RNN3; 2.
DR   STRING; 9606.ENSP00000371572; -.
DR   iPTMnet; B2RNN3; -.
DR   PhosphoSitePlus; B2RNN3; -.
DR   BioMuta; C1QTNF9B; -.
DR   MaxQB; B2RNN3; -.
DR   PaxDb; B2RNN3; -.
DR   PRIDE; B2RNN3; -.
DR   ProteomicsDB; 3442; -.
DR   ProteomicsDB; 3443; -. [B2RNN3-2]
DR   Ensembl; ENST00000382137; ENSP00000371572; ENSG00000205863. [B2RNN3-1]
DR   Ensembl; ENST00000382140; ENSP00000371575; ENSG00000205863. [B2RNN3-1]
DR   GeneID; 387911; -.
DR   KEGG; hsa:387911; -.
DR   UCSC; uc001uoz.3; human. [B2RNN3-1]
DR   CTD; 387911; -.
DR   DisGeNET; 387911; -.
DR   EuPathDB; HostDB:ENSG00000205863.9; -.
DR   GeneCards; C1QTNF9B; -.
DR   HGNC; HGNC:34072; C1QTNF9B.
DR   HPA; HPA056632; -.
DR   MIM; 614148; gene.
DR   neXtProt; NX_B2RNN3; -.
DR   OpenTargets; ENSG00000205863; -.
DR   eggNOG; ENOG410IE67; Eukaryota.
DR   eggNOG; ENOG4112BCC; LUCA.
DR   GeneTree; ENSGT00940000154936; -.
DR   HOGENOM; HOG000085653; -.
DR   HOVERGEN; HBG108220; -.
DR   InParanoid; B2RNN3; -.
DR   OMA; NHYDTAV; -.
DR   OrthoDB; 1258047at2759; -.
DR   PhylomeDB; B2RNN3; -.
DR   TreeFam; TF334029; -.
DR   GenomeRNAi; 387911; -.
DR   PRO; PR:B2RNN3; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   Bgee; ENSG00000205863; Expressed in 70 organ(s), highest expression level in testis.
DR   ExpressionAtlas; B2RNN3; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Collagen; Complete proteome; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    333       Complement C1q and tumor necrosis factor-
FT                                related protein 9B.
FT                                /FTId=PRO_0000348424.
FT   DOMAIN       24     82       Collagen-like 1.
FT   DOMAIN       95    154       Collagen-like 2.
FT   DOMAIN      155    191       Collagen-like 3.
FT   DOMAIN      197    333       C1q. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00368}.
FT   VAR_SEQ      89     99       GDQGSRGSPGK -> EMFRCLWSKME (in isoform
FT                                2). {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_035153.
FT   VAR_SEQ     100    333       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_035154.
SQ   SEQUENCE   333 AA;  34713 MW;  A15F3F7546938A70 CRC64;
     MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGC
     PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP
     QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI
     RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK
     FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE
     MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
//