ID   B1N8M6_HUMAN            Unreviewed;       304 AA.
AC   B1N8M6;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=KIR2DS1 {ECO:0000313|EMBL:ABS18362.1};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DS1 {ECO:0000313|Ensembl:ENSP00000479102};
DE   SubName: Full=Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1 {ECO:0000313|EMBL:AJI81026.1};
GN   Name=KIR2DS1 {ECO:0000313|EMBL:ABS18362.1,
GN   ECO:0000313|Ensembl:ENSP00000479102};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABS18362.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479102, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:ABS18362.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18396209; DOI=10.1016/j.humimm.2008.01.009;
RA   Hou L., Steiner N.K., Chen M., Belle I., Kubit A.L., Ng J.,
RA   Hurley C.K.;
RT   "Limited allelic diversity of stimulatory two-domain killer cell
RT   immunoglobulin-like receptors.";
RL   Hum. Immunol. 69:174-178(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000479102}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:AJI81026.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA   Ranade S., Geraghty D.E., Maiers M.;
RT   "Full Haplotype Sequences of the Killer Immunoglobulin-like Receptor
RT   (KIR) Region in Several Diverse Diploid Individuals using Single
RT   Molecule, Real-Time Sequencing.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CU041340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU464061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU466259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU633846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF423903; ABS18362.1; -; Genomic_DNA.
DR   EMBL; KP420443; AJI81026.1; -; Genomic_DNA.
DR   RefSeq; XP_011546300.1; XM_011547998.1.
DR   RefSeq; XP_011546672.1; XM_011548370.1.
DR   UniGene; Hs.744319; -.
DR   Ensembl; ENST00000615190; ENSP00000479102; ENSG00000275921.
DR   Ensembl; ENST00000616491; ENSP00000480228; ENSG00000276387.
DR   GeneID; 3806; -.
DR   KEGG; hsa:112268360; -.
DR   UCSC; uc032jet.2; human.
DR   CTD; 3806; -.
DR   HGNC; HGNC:6333; KIR2DS1.
DR   OpenTargets; ENSG00000276387; -.
DR   HOVERGEN; HBG074353; -.
DR   OrthoDB; 1055520at2759; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AJI81026.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    304       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015087069.
FT   TRANSMEM    244    265       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    114       IG. {ECO:0000259|SMART:SM00409}.
FT   DOMAIN      134    221       IG. {ECO:0000259|SMART:SM00409}.
SQ   SEQUENCE   304 AA;  33630 MW;  E1F157B22B0D6A22 CRC64;
     MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL
     HREGMFNDTL RLIGEHHDGV SKANFSISRM KQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
     VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT
     FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN
     PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE
     VSYA
//