ID B1ALU3_HUMAN Unreviewed; 1431 AA. AC B1ALU3; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 16-JAN-2019, entry version 114. DE SubName: Full=Adhesion G protein-coupled receptor L2 {ECO:0000313|Ensembl:ENSP00000359762}; DE SubName: Full=Latrophilin 2, isoform CRA_k {ECO:0000313|EMBL:EAX06331.1}; GN Name=ADGRL2 {ECO:0000313|Ensembl:ENSP00000359762}; GN Synonyms=LPHN2 {ECO:0000313|EMBL:EAX06331.1}; GN ORFNames=hCG_14669 {ECO:0000313|EMBL:EAX06331.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000359762, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|EMBL:EAX06331.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:EAX06331.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000359762, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000213|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:rs3-RS3(2011). RN [6] {ECO:0000313|Ensembl:ENSP00000359762} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [7] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [8] {ECO:0000313|Ensembl:ENSP00000485786} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|SAAS:SAAS00547938}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC093154; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC095035; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC113949; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC117944; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL138799; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL157903; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL358939; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL359705; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510734; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471059; EAX06331.1; -; Genomic_DNA. DR UniGene; Hs.24212; -. DR UniGene; Hs.406863; -. DR UniGene; Hs.649282; -. DR EPD; B1ALU3; -. DR jPOST; B1ALU3; -. DR MaxQB; B1ALU3; -. DR PRIDE; B1ALU3; -. DR Ensembl; ENST00000370727; ENSP00000359762; ENSG00000117114. DR Ensembl; ENST00000627151; ENSP00000485786; ENSG00000117114. DR UCSC; uc057hwz.1; human. DR EuPathDB; HostDB:ENSG00000117114.19; -. DR HGNC; HGNC:18582; ADGRL2. DR OpenTargets; ENSG00000117114; -. DR eggNOG; KOG3545; Eukaryota. DR eggNOG; KOG4193; Eukaryota. DR eggNOG; KOG4729; Eukaryota. DR eggNOG; ENOG410XSD2; LUCA. DR GeneTree; ENSGT00940000156348; -. DR HOGENOM; HOG000049065; -. DR HOVERGEN; HBG052337; -. DR ChiTaRS; ADGRL2; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000117114; Expressed in 103 organ(s), highest expression level in right lung. DR ExpressionAtlas; B1ALU3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR Gene3D; 4.10.1240.10; -; 1. DR InterPro; IPR032471; GAIN_dom_N. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR003924; GPCR_2_latrophilin. DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR InterPro; IPR000203; GPS. DR InterPro; IPR031240; Latrophilin-2. DR InterPro; IPR000922; Lectin_gal-bd_dom. DR InterPro; IPR003112; Olfac-like_dom. DR PANTHER; PTHR12011:SF61; PTHR12011:SF61; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF16489; GAIN; 1. DR Pfam; PF02140; Gal_Lectin; 1. DR Pfam; PF01825; GPS; 1. DR Pfam; PF02793; HRM; 1. DR Pfam; PF02354; Latrophilin; 2. DR Pfam; PF02191; OLF; 1. DR PRINTS; PR00249; GPCRSECRETIN. DR PRINTS; PR01444; LATROPHILIN. DR SMART; SM00303; GPS; 1. DR SMART; SM00008; HormR; 1. DR SMART; SM00284; OLF; 1. DR SUPFAM; SSF111418; SSF111418; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR PROSITE; PS50221; GPS; 1. DR PROSITE; PS51132; OLF; 1. DR PROSITE; PS50228; SUEL_LECTIN; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446}; KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998}; KW Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:B1ALU3, KW ECO:0000213|MaxQB:B1ALU3, ECO:0000213|PeptideAtlas:B1ALU3}; KW Receptor {ECO:0000256|SAAS:SAAS00978998}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|SAAS:SAAS00978998}; KW Transmembrane {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1431 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014567453. FT TRANSMEM 845 870 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 882 900 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 906 930 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 951 971 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 991 1014 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1051 1073 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1079 1102 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 41 130 SUEL-type lectin. FT {ECO:0000259|PROSITE:PS50228}. FT DOMAIN 135 394 Olfactomedin-like. FT {ECO:0000259|PROSITE:PS51132}. FT DOMAIN 468 525 G_PROTEIN_RECEP_F2_3. FT {ECO:0000259|PROSITE:PS50227}. FT DOMAIN 785 836 GPS. {ECO:0000259|PROSITE:PS50221}. FT DOMAIN 847 1103 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. FT DISULFID 136 318 {ECO:0000256|PROSITE-ProRule:PRU00446}. SQ SEQUENCE 1431 AA; 160515 MW; 4DC1CDDC11D08A96 CRC64; MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENINNYRVCD GYYNTDLPGS WVLGAFALLC LLGLTWSFGL LFINEETIVM AYLFTIFNAF QGVFIFIFHC ALQKKVRKEY GKCFRHSYCC GGLPTESPHS SVKASTTRTS ARYSSGTQSR IRRMWNDTVR KQSESSFISG DINSTSTLNQ GHSLNNARDT SAMDTLPLNG NFNNSYSLHK GDYNDSVQVV DCGLSLNDTA FEKMIISELV HNNLRGSSKT HNLELTLPVK PVIGGSSSED DAIVADASSL MHSDNPGLEL HHKELEAPLI PQRTHSLLYQ PQKKVKSEGT DSYVSQLTAE AEDHLQSPNR DSLYTSMPNL RDSPYPESSP DMEEDLSPSR RSENEDIYYK SMPNLGAGHQ LQMCYQISRG NSDGYIIPIN KEGCIPEGDV REGQMQLVTS L //