ID B1ALF6_HUMAN Unreviewed; 278 AA. AC B1ALF6; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 16-JAN-2019, entry version 84. DE SubName: Full=Probable global transcription activator SNF2L2 {ECO:0000313|Ensembl:ENSP00000305411}; GN Name=SMARCA2 {ECO:0000313|Ensembl:ENSP00000305411}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000305411, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000305411, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] {ECO:0000213|PubMed:17081983} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., RA Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in RT signaling networks."; RL Cell 127:635-648(2006). RN [3] {ECO:0000213|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [4] {ECO:0000213|PubMed:18318008} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18318008; DOI=10.1002/pmic.200700884; RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., RA Zou H., Gu J.; RT "Large-scale phosphoproteome analysis of human liver tissue by RT enrichment and fractionation of phosphopeptides with strong anion RT exchange chromatography."; RL Proteomics 8:1346-1361(2008). RN [5] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:ra46-RA46(2009). RN [6] {ECO:0000213|PubMed:20068231} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., RA Mann M.; RT "Quantitative phosphoproteomics reveals widespread full RT phosphorylation site occupancy during mitosis."; RL Sci. Signal. 3:ra3-RA3(2010). RN [7] {ECO:0000313|Ensembl:ENSP00000305411} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [8] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [9] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL138755; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL359076; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL591644; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001276329.1; NM_001289400.1. DR UniGene; Hs.298990; -. DR UniGene; Hs.644901; -. DR ProteinModelPortal; B1ALF6; -. DR jPOST; B1ALF6; -. DR MaxQB; B1ALF6; -. DR PeptideAtlas; B1ALF6; -. DR PRIDE; B1ALF6; -. DR Ensembl; ENST00000302401; ENSP00000305411; ENSG00000080503. DR GeneID; 6595; -. DR UCSC; uc003zhe.4; human. DR CTD; 6595; -. DR EuPathDB; HostDB:ENSG00000080503.20; -. DR HGNC; HGNC:11098; SMARCA2. DR OpenTargets; ENSG00000080503; -. DR GeneTree; ENSGT00940000154821; -. DR HOGENOM; HOG000049057; -. DR HOVERGEN; HBG062263; -. DR OrthoDB; 685477at2759; -. DR ChiTaRS; SMARCA2; human. DR GenomeRNAi; 6595; -. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000080503; Expressed in 237 organ(s), highest expression level in testis. DR ExpressionAtlas; B1ALF6; baseline and differential. DR GO; GO:0016514; C:SWI/SNF complex; IEA:InterPro. DR GO; GO:0016887; F:ATPase activity; IEA:InterPro. DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro. DR Gene3D; 1.20.920.10; -; 1. DR InterPro; IPR001487; Bromodomain. DR InterPro; IPR036427; Bromodomain-like_sf. DR InterPro; IPR018359; Bromodomain_CS. DR InterPro; IPR030088; SMARCA2. DR PANTHER; PTHR10799:SF541; PTHR10799:SF541; 1. DR Pfam; PF00439; Bromodomain; 1. DR PRINTS; PR00503; BROMODOMAIN. DR SMART; SM00297; BROMO; 1. DR SUPFAM; SSF47370; SSF47370; 1. DR PROSITE; PS00633; BROMODOMAIN_1; 1. DR PROSITE; PS50014; BROMODOMAIN_2; 1. PE 1: Evidence at protein level; KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035, KW ECO:0000256|SAAS:SAAS00979529}; Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:B1ALF6, KW ECO:0000213|MaxQB:B1ALF6, ECO:0000213|PeptideAtlas:B1ALF6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 278 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002761800. FT DOMAIN 107 177 Bromo. {ECO:0000259|PROSITE:PS50014}. FT COILED 40 60 {ECO:0000256|SAM:Coils}. FT COILED 187 217 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 278 AA; 31979 MW; 5766E7798DBF003B CRC64; MLMKRLAARC FAGLLILSPL TVISDSRPAD SGKAIEDGNL EEMEEEVRLK KRKRRRNVDK DPAKEDVEKA KKRRGRPPAE KLSPNPPKLT KQMNAIIDTV INYKDSSGRQ LSEVFIQLPS RKELPEYYEL IRKPVDFKKI KERIRNHKYR SLGDLEKDVM LLCHNAQTFN LEGSQIYEDS IVLQSVFKSA RQKIAKEEES EDESNEEEEE EDEEESESEA KSVKVKIKLN KKDDKGRDKG KGKKRPNRGK AKPVVSDFDS DEEQDEREQS EGSGTDDE //