ID   B1ALD9_HUMAN            Unreviewed;       808 AA.
AC   B1ALD9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 80.
DE   SubName: Full=Periostin {ECO:0000313|Ensembl:ENSP00000369073};
GN   Name=POSTN {ECO:0000313|Ensembl:ENSP00000369073};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000369073, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000369073, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000369073}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AL138679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL646087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317446.1; NM_001330517.1.
DR   UniGene; Hs.136348; -.
DR   UniGene; Hs.721018; -.
DR   ProteinModelPortal; B1ALD9; -.
DR   jPOST; B1ALD9; -.
DR   MaxQB; B1ALD9; -.
DR   PeptideAtlas; B1ALD9; -.
DR   PRIDE; B1ALD9; -.
DR   Ensembl; ENST00000379749; ENSP00000369073; ENSG00000133110.
DR   GeneID; 10631; -.
DR   UCSC; uc058wmq.1; human.
DR   CTD; 10631; -.
DR   EuPathDB; HostDB:ENSG00000133110.14; -.
DR   HGNC; HGNC:16953; POSTN.
DR   OpenTargets; ENSG00000133110; -.
DR   eggNOG; KOG1437; Eukaryota.
DR   eggNOG; COG2335; LUCA.
DR   GeneTree; ENSGT00530000063860; -.
DR   HOGENOM; HOG000220865; -.
DR   HOVERGEN; HBG000715; -.
DR   OrthoDB; 1437416at2759; -.
DR   ChiTaRS; POSTN; human.
DR   GenomeRNAi; 10631; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   Bgee; ENSG00000133110; Expressed in 203 organ(s), highest expression level in periodontal ligament.
DR   ExpressionAtlas; B1ALD9; baseline and differential.
DR   Gene3D; 2.30.180.10; -; 4.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR036378; FAS1_dom_sf.
DR   InterPro; IPR000782; FAS1_domain.
DR   InterPro; IPR016666; TGFBI/POSTN.
DR   Pfam; PF02469; Fasciclin; 4.
DR   PIRSF; PIRSF016553; BIGH3_OSF2; 1.
DR   SMART; SM00554; FAS1; 4.
DR   SUPFAM; SSF82153; SSF82153; 4.
DR   PROSITE; PS51041; EMI; 1.
DR   PROSITE; PS50213; FAS1; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:B1ALD9,
KW   ECO:0000213|PeptideAtlas:B1ALD9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    808       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002761412.
FT   DOMAIN       40     94       EMI. {ECO:0000259|PROSITE:PS51041}.
FT   DOMAIN       97    230       FAS1. {ECO:0000259|PROSITE:PS50213}.
FT   DOMAIN      234    365       FAS1. {ECO:0000259|PROSITE:PS50213}.
FT   DOMAIN      368    492       FAS1. {ECO:0000259|PROSITE:PS50213}.
FT   DOMAIN      496    628       FAS1. {ECO:0000259|PROSITE:PS50213}.
SQ   SEQUENCE   808 AA;  90143 MW;  CC5D125B8359A3A5 CRC64;
     MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC
     KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS
     KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK
     NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF
     IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL
     MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL
     IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM
     DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG
     RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA
     FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND
     TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST
     FKEIPVTVYT TKIITKVVEP KIKVIEGSLQ PIIKTEGPTL TKVKIEGEPE FRLIKEGETI
     TEVIHGEPII KKYTKIIDGV PVEITEKETR EERIITGPEI KYTRISTGGG ETEETLKKLL
     QEDTPVRKLQ ANKKVQGSRR RLREGRSQ
//