ID   B1AKZ9_HUMAN            Unreviewed;       365 AA.
AC   B1AKZ9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   05-DEC-2018, entry version 84.
DE   SubName: Full=Bone morphogenetic protein 7 {ECO:0000313|Ensembl:ENSP00000379205};
GN   Name=BMP7 {ECO:0000313|Ensembl:ENSP00000379205};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379205, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379205, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000379205}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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DR   EMBL; AL122058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B1AKZ9; -.
DR   EPD; B1AKZ9; -.
DR   MaxQB; B1AKZ9; -.
DR   PeptideAtlas; B1AKZ9; -.
DR   PRIDE; B1AKZ9; -.
DR   Ensembl; ENST00000395864; ENSP00000379205; ENSG00000101144.
DR   UCSC; uc061xxp.1; human.
DR   EuPathDB; HostDB:ENSG00000101144.12; -.
DR   HGNC; HGNC:1074; BMP7.
DR   OpenTargets; ENSG00000101144; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   eggNOG; ENOG410XT8Z; LUCA.
DR   GeneTree; ENSGT00940000156490; -.
DR   HOGENOM; HOG000249476; -.
DR   HOVERGEN; HBG004860; -.
DR   ChiTaRS; BMP7; human.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000101144; Expressed in 205 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; B1AKZ9; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; PTHR11848; 2.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
KW   Growth factor {ECO:0000256|RuleBase:RU000354,
KW   ECO:0000256|SAAS:SAAS00516085};
KW   Proteomics identification {ECO:0000213|MaxQB:B1AKZ9,
KW   ECO:0000213|PeptideAtlas:B1AKZ9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00516087};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    365       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002761878.
FT   DOMAIN      240    365       TGF_BETA_2.
FT                                {ECO:0000259|PROSITE:PS51362}.
SQ   SEQUENCE   365 AA;  41982 MW;  7D562A5D28BE9DEA CRC64;
     MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS
     ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS
     LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY
     IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR
     HNLGLQLSVE TLDENSSSDQ RQACKKHELY VSFRDLGWQD WIIAPEGYAA YYCEGECAFP
     LNSYMNATNH AIVQTLVHFI NPETVPKPCC APTQLNAISV LYFDDSSNVI LKKYRNMVVR
     ACGCH
//