ID B1AK81_HUMAN Unreviewed; 301 AA. AC B1AK81; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 16-JAN-2019, entry version 87. DE RecName: Full=GPI-anchor transamidase {ECO:0000256|RuleBase:RU365060}; DE Short=GPI transamidase {ECO:0000256|RuleBase:RU365060}; DE EC=3.-.-.- {ECO:0000256|RuleBase:RU365060}; DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class K protein {ECO:0000256|RuleBase:RU365060}; GN Name=PIGK {ECO:0000256|RuleBase:RU365060, ECO:0000313|EMBL:EAX06382.1, GN ECO:0000313|Ensembl:ENSP00000388854}; GN ORFNames=hCG_22810 {ECO:0000313|EMBL:EAX06382.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388854, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|EMBL:EAX06382.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:EAX06382.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000388854, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000388854} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [6] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: Mediates GPI anchoring in the endoplasmic reticulum, by CC replacing a protein's C-terminal GPI attachment signal peptide CC with a pre-assembled GPI. During this transamidation reaction, the CC GPI transamidase forms a carbonyl intermediate with the substrate CC protein. {ECO:0000256|RuleBase:RU365060}. CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol- CC anchor biosynthesis. {ECO:0000256|RuleBase:RU365060}. CC -!- SUBUNIT: Forms a complex with PIGT, PIGS, PIGU and GAA1. CC {ECO:0000256|RuleBase:RU365060}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU365060}; Single-pass type I membrane CC protein {ECO:0000256|RuleBase:RU365060}. CC -!- SIMILARITY: Belongs to the peptidase C13 family. CC {ECO:0000256|RuleBase:RU365060}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC093433; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC113935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL035409; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876885; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471059; EAX06382.1; -; Genomic_DNA. DR UniGene; Hs.178305; -. DR jPOST; B1AK81; -. DR MaxQB; B1AK81; -. DR PRIDE; B1AK81; -. DR Ensembl; ENST00000445065; ENSP00000388854; ENSG00000142892. DR UCSC; uc009wbx.4; human. DR EuPathDB; HostDB:ENSG00000142892.14; -. DR HGNC; HGNC:8965; PIGK. DR OpenTargets; ENSG00000142892; -. DR eggNOG; KOG1349; Eukaryota. DR eggNOG; COG5206; LUCA. DR GeneTree; ENSGT00940000156273; -. DR HOGENOM; HOG000204398; -. DR HOVERGEN; HBG027488; -. DR UniPathway; UPA00196; -. DR ChiTaRS; PIGK; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000142892; Expressed in 216 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; B1AK81; baseline and differential. DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:UniProtKB-UniRule. DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW. DR GO; GO:0003923; F:GPI-anchor transamidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:UniProtKB-UniRule. DR InterPro; IPR028361; GPI_transamidase. DR InterPro; IPR001096; Peptidase_C13. DR PANTHER; PTHR12000; PTHR12000; 1. DR PANTHER; PTHR12000:SF1; PTHR12000:SF1; 1. DR Pfam; PF01650; Peptidase_C13; 1. DR PRINTS; PR00776; HEMOGLOBNASE. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW GPI-anchor biosynthesis {ECO:0000256|RuleBase:RU365060}; KW Hydrolase {ECO:0000256|RuleBase:RU365060}; KW Membrane {ECO:0000256|RuleBase:RU365060}; KW Protease {ECO:0000256|RuleBase:RU365060}; KW Proteomics identification {ECO:0000213|EPD:B1AK81, KW ECO:0000213|MaxQB:B1AK81, ECO:0000213|PeptideAtlas:B1AK81}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|RuleBase:RU365060}; KW Thiol protease {ECO:0000256|RuleBase:RU365060}; KW Transmembrane {ECO:0000256|RuleBase:RU365060}; KW Transmembrane helix {ECO:0000256|RuleBase:RU365060}. FT SIGNAL 1 27 {ECO:0000256|RuleBase:RU365060}. FT CHAIN 28 301 GPI-anchor transamidase. FT {ECO:0000256|RuleBase:RU365060}. FT /FTId=PRO_5014567451. FT TRANSMEM 270 289 Helical. {ECO:0000256|RuleBase:RU365060}. SQ SEQUENCE 301 AA; 34313 MW; 87FA33929EEC4B68 CRC64; MAVTDSLSRA ATVLATVLLL SFGSVAASHI EVTVENFLRV LTGRIPPSTP RSKRLLSDDR SNILIYMTGH GGNGFLKFQD SEEITNIELA DAFEQMWQKR RYNELLFIID TCQGASMYER FYSPNIMALA SSQVGEDSLS HQPDPAIGVH LMDRYTFYVL EFLEEINPAS QTNMNDLFQV CPKSLCVSTP GHRTDLFQRD PKNVLITDFF GSVRKVEITT ETIKLQQDSE IMESSYKEDQ MDEKLMEPLK YAEQLPVAQI IHQKPKLKDW HPPGGFILGL WALIIMVFFK TYGIKHMKFI F //