ID   B1AJS1_HUMAN            Unreviewed;      1228 AA.
AC   B1AJS1;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 86.
DE   SubName: Full=Astrotactin-1 {ECO:0000313|Ensembl:ENSP00000356629};
GN   Name=ASTN1 {ECO:0000313|Ensembl:ENSP00000356629};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356629, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356629, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000356629}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL021398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL022145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL031290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF454939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001273093.1; NM_001286164.1.
DR   UniGene; Hs.495897; -.
DR   ProteinModelPortal; B1AJS1; -.
DR   PeptideAtlas; B1AJS1; -.
DR   PRIDE; B1AJS1; -.
DR   Ensembl; ENST00000367657; ENSP00000356629; ENSG00000152092.
DR   GeneID; 460; -.
DR   UCSC; uc001glb.3; human.
DR   CTD; 460; -.
DR   EuPathDB; HostDB:ENSG00000152092.15; -.
DR   HGNC; HGNC:773; ASTN1.
DR   OpenTargets; ENSG00000152092; -.
DR   eggNOG; ENOG410IHIU; Eukaryota.
DR   eggNOG; ENOG4110VB2; LUCA.
DR   GeneTree; ENSGT00390000003140; -.
DR   HOGENOM; HOG000034112; -.
DR   HOVERGEN; HBG050597; -.
DR   OrthoDB; 39300at2759; -.
DR   ChiTaRS; ASTN1; human.
DR   GenomeRNAi; 460; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000152092; Expressed in 132 organ(s), highest expression level in entorhinal cortex.
DR   ExpressionAtlas; B1AJS1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   InterPro; IPR026995; Astrotactin.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR16592; PTHR16592; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B1AJS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1228       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002759907.
FT   TRANSMEM    151    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    386    404       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      462    499       EGF-like. {ECO:0000259|SMART:SM00181}.
FT   DOMAIN      603    644       EGF-like. {ECO:0000259|SMART:SM00181}.
FT   DOMAIN      651    700       EGF-like. {ECO:0000259|SMART:SM00181}.
FT   DOMAIN      803    991       MACPF. {ECO:0000259|SMART:SM00457}.
SQ   SEQUENCE   1228 AA;  136486 MW;  AC672AE9B387D2D0 CRC64;
     MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE NDLSIMHSPS
     ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT EDIPLVRWRQ QWLENGTLLF
     HIHHQDGAPS LPGQDPTEEP QHESAEEELR ILHISVMGGM IALLLSILCL VMILYTRRRW
     CKRRRVPQPQ KSASAEAANE IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD
     GYEYDITDLR HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK
     YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG TEAENDPQLT
     FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC SSHVNCPLVV KITLHVPEHL
     IADGSRFILL EGSQLDASDW LNPAQVVLFS QQNSSGPWAM DLCARRLLDP CEHQCDPETG
     ECLCYEGYMK DPVHKHLCIR NEWGTNQGPW PYTIFQRGFD LVLGEQPSDK IFRFTYTLGE
     GMWLPLSKSF VIPPAELAIN PSAKCKTDMT VMEDAVEVRE ELMTSSSFDS LEVLLDSFGP
     VRDCSKDNGG CSKNFRCISD RKLDSTGCVC PSGLSPMKDS SGCYDRHIGV DCSDGFNGGC
     EQLCLQQMAP FPDDPTLYNI LMFCGCIEDY KLGVDGRSCQ LITETCPEGS DCGESRELPM
     NQTLFGEMFF GYNNHSKEVA AGQVLKGTFR QNNFARGLDQ QLPDGLVVAT VPLENQCLEE
     ISEPTPDPDF LTGMVNFSEV SGYPVLQHWK VRSVMYHIKL NQVAISQALS NALHSLDGAT
     SRADFVALLD QFGNHYIQEA IYGFEESCSI WYPNKQVQRR LWLEYEDISK GNSPSDESEE
     RERDPKVLTF PEYITSLSDS GTKHMAAGVR MECHSKGRCP SSCPLCHVTS SPDTPAEPVL
     LEVTKAAPIY ELVTNNQTQR LLQEATMSSL WCSGTGDVIE DWCRCDSTAF GADGLPTCAP
     LPQPVLRLST VHEPSSTLVV LEWEHSEPPI GVQIVDYLLR QEKVTDRMDH SKVETETVLS
     FVDDIISGAK SPCAMPSQVP DKQLTTISLI IRCLEPDTIY MFTLWGVDNT GRRSRPSDVI
     VKTPCPVVDD VKAQEIADKI YNLFNGYTSG KEQQTAYNTL LDLGSPTLHR VLYHYNQHYE
     SFGEFTWRCE DELGPRLPAC WDSQRSCR
//