ID   B1AHJ6_HUMAN            Unreviewed;       141 AA.
AC   B1AHJ6;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 72.
DE   RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|RuleBase:RU365018};
DE            EC=2.8.2.20 {ECO:0000256|RuleBase:RU365018};
DE   Flags: Fragment;
GN   Name=TPST2 {ECO:0000313|Ensembl:ENSP00000403875};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403875, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000403875, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2] {ECO:0000313|Ensembl:ENSP00000403875}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within
CC       acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate
CC       (PAPS) as cosubstrate. {ECO:0000256|RuleBase:RU365018}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] =
CC         adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-
CC         [protein]; Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:11688, ChEBI:CHEBI:15378, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:65286;
CC         EC=2.8.2.20; Evidence={ECO:0000256|RuleBase:RU365018};
CC   -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC       {ECO:0000256|RuleBase:RU365018}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KF511430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z95115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; B1AHJ6; -.
DR   PeptideAtlas; B1AHJ6; -.
DR   PRIDE; B1AHJ6; -.
DR   Ensembl; ENST00000442495; ENSP00000403875; ENSG00000128294.
DR   UCSC; uc062cqe.1; human.
DR   EuPathDB; HostDB:ENSG00000128294.15; -.
DR   HGNC; HGNC:12021; TPST2.
DR   OpenTargets; ENSG00000128294; -.
DR   eggNOG; KOG3988; Eukaryota.
DR   eggNOG; ENOG410XQ2X; LUCA.
DR   GeneTree; ENSGT00390000006030; -.
DR   ChiTaRS; TPST2; human.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000128294; Expressed in 205 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; B1AHJ6; baseline and differential.
DR   GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006478; P:peptidyl-tyrosine sulfation; IEA:InterPro.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR026634; TPST.
DR   PANTHER; PTHR12788; PTHR12788; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:B1AHJ6,
KW   ECO:0000213|MaxQB:B1AHJ6, ECO:0000213|PeptideAtlas:B1AHJ6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU365018}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    141       Protein-tyrosine sulfotransferase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008409926.
FT   NON_TER     141    141       {ECO:0000313|Ensembl:ENSP00000403875}.
SQ   SEQUENCE   141 AA;  15526 MW;  571825727AAC855B CRC64;
     MRLSVRRVLL AAGCALVLVL AVQLGQQVLE CRAVLAGLRS PRGAMRPEQE ELVMVGTNHV
     EYRYGKAMPL IFVGGVPRSG TTLMRAMLDA HPEVRCGEET RIIPRVLAMR QAWSKSGREK
     LRLDEAGVTD EVLDAAMQAF I
//