ID   B1AH95_HUMAN            Unreviewed;       141 AA.
AC   B1AH95;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   SubName: Full=Apolipoprotein L1 {ECO:0000313|Ensembl:ENSP00000391206};
DE   SubName: Full=cDNA FLJ59906, moderately similar to Apolipoprotein-L1 {ECO:0000313|EMBL:BAG58852.1};
GN   Name=APOL1 {ECO:0000313|Ensembl:ENSP00000391206};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391206, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000391206, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2] {ECO:0000313|EMBL:BAG58852.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thalamus {ECO:0000313|EMBL:BAG58852.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000391206}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; Z82215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK296099; BAG58852.1; -; mRNA.
DR   RefSeq; NP_663318.1; NM_145343.2.
DR   UniGene; Hs.114309; -.
DR   MaxQB; B1AH95; -.
DR   PeptideAtlas; B1AH95; -.
DR   PRIDE; B1AH95; -.
DR   Ensembl; ENST00000422471; ENSP00000391206; ENSG00000100342.
DR   Ensembl; ENST00000433768; ENSP00000392514; ENSG00000100342.
DR   GeneID; 8542; -.
DR   UCSC; uc062dte.1; human.
DR   CTD; 8542; -.
DR   EuPathDB; HostDB:ENSG00000100342.20; -.
DR   HGNC; HGNC:618; APOL1.
DR   OpenTargets; ENSG00000100342; -.
DR   PharmGKB; PA24904; -.
DR   eggNOG; ENOG410KC8P; Eukaryota.
DR   eggNOG; ENOG4110P7Y; LUCA.
DR   GeneTree; ENSGT00510000046700; -.
DR   OrthoDB; 1060131at2759; -.
DR   ChiTaRS; APOL1; human.
DR   GenomeRNAi; 8542; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000100342; Expressed in 207 organ(s), highest expression level in epithelium of bronchus.
DR   ExpressionAtlas; B1AH95; baseline and differential.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Lipoprotein {ECO:0000313|EMBL:BAG58852.1};
KW   Proteomics identification {ECO:0000213|MaxQB:B1AH95,
KW   ECO:0000213|PeptideAtlas:B1AH95};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    141       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014084694.
FT   NON_TER     141    141       {ECO:0000313|Ensembl:ENSP00000392514}.
SQ   SEQUENCE   141 AA;  14954 MW;  7E19BDB78F832AA0 CRC64;
     MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM
     DPGPAGSRGD SGEPCTLRPA CRGQRQHGGA SRISAEGPAP MPRRRTPSTA HLRVPKTSRR
     NLLCMRAVSL LRMPLSISRK K
//