ID   B0YIW2_HUMAN            Unreviewed;       117 AA.
AC   B0YIW2;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 75.
DE   SubName: Full=Apolipoprotein C-III variant 1 {ECO:0000313|EMBL:ACA05941.1};
GN   Name=APOC3 {ECO:0000313|EMBL:ACA05941.1,
GN   ECO:0000313|Ensembl:ENSP00000364494};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACA05941.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000364494, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|EMBL:ACA05941.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Stockwell T.B., Busam D.A., Ferriera S.M., Brownley A.N.,
RA   Strausberg R.L., Kirkness E.F., Rogers Y.-H., Levy S.;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000364494}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [6] {ECO:0000313|Ensembl:ENSP00000486182}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
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DR   EMBL; AP006216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF444950; ACA05941.1; -; Genomic_DNA.
DR   UniGene; Hs.73849; -.
DR   EPD; B0YIW2; -.
DR   jPOST; B0YIW2; -.
DR   MaxQB; B0YIW2; -.
DR   PeptideAtlas; B0YIW2; -.
DR   PRIDE; B0YIW2; -.
DR   Ensembl; ENST00000375345; ENSP00000364494; ENSG00000110245.
DR   Ensembl; ENST00000630701; ENSP00000486182; ENSG00000110245.
DR   UCSC; uc058hqw.1; human.
DR   EuPathDB; HostDB:ENSG00000110245.11; -.
DR   HGNC; HGNC:610; APOC3.
DR   OpenTargets; ENSG00000110245; -.
DR   eggNOG; ENOG410JE3N; Eukaryota.
DR   eggNOG; ENOG4111APE; LUCA.
DR   GeneTree; ENSGT00390000015395; -.
DR   HOGENOM; HOG000247042; -.
DR   OMA; KDYWSTF; -.
DR   ChiTaRS; APOC3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110245; Expressed in 91 organ(s), highest expression level in liver.
DR   ExpressionAtlas; B0YIW2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.225.30; -; 1.
DR   InterPro; IPR008403; Apo-CIII.
DR   InterPro; IPR038195; Apo_CIII_sf.
DR   PANTHER; PTHR14225; PTHR14225; 1.
DR   Pfam; PF05778; Apo-CIII; 1.
DR   ProDom; PD010414; Apo-CIII; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Lipoprotein {ECO:0000313|EMBL:ACA05941.1};
KW   Proteomics identification {ECO:0000213|EPD:B0YIW2,
KW   ECO:0000213|MaxQB:B0YIW2, ECO:0000213|PeptideAtlas:B0YIW2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     38       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        39    117       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014084658.
SQ   SEQUENCE   117 AA;  12816 MW;  63630ED731A71D40 CRC64;
     MGTWGAPHRT LPCRNRGAMQ PRVLLVVALL ALLASARASE AEDASLLSFM QGYMKHATKT
     AKDALSSVQE SQVAQQARGW VTDGFSSLKD YWSTVKDKFS EFWDLDPEVR PTSAVAA
//