ID   B0UXQ0_HUMAN            Unreviewed;       365 AA.
AC   B0UXQ0; A0A0D6K955;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   13-FEB-2019, entry version 111.
DE   SubName: Full=HLA class I histocompatibility antigen, A-3 alpha chain {ECO:0000313|Ensembl:ENSP00000450169};
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CAQ16345.1, ECO:0000313|EMBL:CDO33932.1};
GN   Name=HLA-A {ECO:0000313|EMBL:CAQ16345.1,
GN   ECO:0000313|Ensembl:ENSP00000450169};
GN   Synonyms=HLA {ECO:0000313|EMBL:ASU50344.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAQ16345.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000450169, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:CAQ16345.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ16345.1};
RA   Heinold A., Schaller-Suefling E., Opelz G., Scherer S., Tran T.H.;
RT   "Identification of two novel HLA alleles, HLA-A*02010103 and HLA-
RT   B*4455, and characterization of the complete genomic sequence of HLA-
RT   A*290201.";
RL   Tissue Antigens 72:397-400(2008).
RN   [3] {ECO:0000313|EMBL:CAQ16345.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ16345.1};
RA   Tran H.;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5] {ECO:0000313|EMBL:ADQ48108.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21859426; DOI=10.1111/j.1399-0039.2011.01752.x;
RA   Xu Y., Li Z., Zou H., Deng Z.;
RT   "Two novel HLA-A alleles, A*29:02:01:02 and A*68:01:01:02, were
RT   identified by genomic full-length cloning and sequencing.";
RL   Tissue Antigens 79:72-74(2012).
RN   [6] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [7] {ECO:0000313|EMBL:CDO33932.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Peripheral blood {ECO:0000313|EMBL:CDO33932.1};
RA   McWhinnie A.J., Robinson J.;
RT   "Confirmatory sequencing of HLA-A*29:02:01:02.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:CEG62396.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Voorter C.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:CEG62396.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gerritsen K.E.H., Olieslagers T.I., Groeneweg M., Voorter C.E.M.,
RA   Tilanus M.G.J.;
RT   "An improved and validated RNA HLA class I SBT approach for obtaining
RT   full length coding sequences.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [11] {ECO:0000313|EMBL:CRX74685.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hoefler B.C., Straight P.D.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|Ensembl:ENSP00000450169}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [13] {ECO:0000313|EMBL:CTQ48004.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:CUA55064.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:CRX74685.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rikkerink E.H.A., Fineran P.C.;
RT   "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the
RT   Causal Agent of Kiwifruit Canker Disease.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:SBV08748.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lavstsen T., Jespersen J.S.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:CUA55064.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Marsh S.G.E.;
RT   "Full-length genomic HLA sequences.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:CQR91464.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28547825; DOI=.1111/tan.13057;
RA   Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G.,
RA   Dahl A., Winkler S., Lange V., Bohme I., Schmidt A.H.;
RT   "Dual redundant sequencing strategy: Full-length gene characterisation
RT   of 1056 novel and confirmatory HLA alleles.";
RL   HLA 90:79-87(2017).
RN   [19] {ECO:0000313|EMBL:ASU50344.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Balz V., Krause S., Enczmann J., Fischer J.;
RT   "More than 130 novel variants of HLA class 1 genes detected in German
RT   Stem Cell Donor Registry and Terasaki samples.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:SMB18742.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Masson D., Colom S.;
RT   "x.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:AWB14529.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yin Y., Takemura P., Bolon Y.-T., Springer B., Saito K., Reed E.F.,
RA   Zhang Q.J.;
RT   "Advances in HLA clinical relevant exon novelty detection from over
RT   21,000 donor recruitment samples.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:SNQ25991.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kim H.J., Triplett B.A.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:SBV08748.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Marsh S.G.E.;
RT   "Full-length genomic HLA sequences.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:ASU61678.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sun Z.S., Albrecht U., Echele G., Lee C.C.;
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:SNQ25991.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Groeneweg M., Matern B., Palusci F., Meertens C., Tilanus M.G.J.,
RA   Voorter C.E.M.;
RT   "Group specific, unambiguous full-length gene HLA Class I typing by
RT   Sanger sequencing: a robust SSBT Strategy for typing and a golden
RT   reference for next generation sequencing approaches.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:AUD08728.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.;
RT   "Novel HLA Class I alleles.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|EMBL:AUQ33054.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Cereb N., Yang S.Y.;
RT   "HLA new alleles found by Histogenetics.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:ASA47552.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hurley C.K., Hou L., Lazaro A., Gerfen J., Enriquez E., Galarza P.,
RA   Rodriguez Cardozo M.B., Halagan M., Maiers M., Behm D., Ng J.;
RT   "Next generation sequencing characterizes the extent of HLA diversity
RT   in an Argentinian registry population.";
RL   HLA 91:175-186(2018).
RN   [29] {ECO:0000313|EMBL:AUQ33054.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Marsh S.G.E.;
RT   "Nomenclature for factors of the HLA system, update December 2017.";
RL   Int. J. Immunogenet. 0:0-0(2018).
RN   [30] {ECO:0000313|EMBL:AWX41293.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Go L.Y., Mitchell J.A.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|EMBL:SPQ44332.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M.,
RA   Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Rusch D.,
RA   Podicherti R., Tsui H.-C.T., Winkler M.E.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system. {ECO:0000256|SAAS:SAAS00291881}.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}.
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DR   EMBL; CR382333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; HM595424; ADQ48108.1; -; Genomic_DNA.
DR   EMBL; KY350869; ASA47552.1; -; Genomic_DNA.
DR   EMBL; KY762290; ASG91926.1; -; Genomic_DNA.
DR   EMBL; KY419453; ASU50344.1; -; Genomic_DNA.
DR   EMBL; MF474228; ASU61678.1; -; Genomic_DNA.
DR   EMBL; MG189581; AUD08728.1; -; Genomic_DNA.
DR   EMBL; MG450945; AUQ33054.1; -; Genomic_DNA.
DR   EMBL; MF069203; AWB14529.1; -; Genomic_DNA.
DR   EMBL; MH156679; AWX41293.1; -; Genomic_DNA.
DR   EMBL; AM944568; CAQ16345.1; -; Genomic_DNA.
DR   EMBL; HG965144; CDO33932.1; -; Genomic_DNA.
DR   EMBL; LN623521; CEG62396.1; -; mRNA.
DR   EMBL; LN832586; CQR91464.2; -; Genomic_DNA.
DR   EMBL; LN868254; CRX74685.1; -; Genomic_DNA.
DR   EMBL; LN873234; CTQ48004.1; -; Genomic_DNA.
DR   EMBL; LN877321; CUA55064.1; -; Genomic_DNA.
DR   EMBL; LN877349; CUA55092.1; -; Genomic_DNA.
DR   EMBL; LN880521; CUI25654.1; -; Genomic_DNA.
DR   EMBL; LN999579; CUX90972.1; -; Genomic_DNA.
DR   EMBL; LN999622; CUX91015.1; -; Genomic_DNA.
DR   EMBL; LT596644; SBV08748.1; -; Genomic_DNA.
DR   EMBL; LT599182; SBW38403.1; -; Genomic_DNA.
DR   EMBL; LT599194; SBW38415.1; -; Genomic_DNA.
DR   EMBL; LT838207; SMB18742.1; -; Genomic_DNA.
DR   EMBL; LT838208; SMB18743.1; -; Genomic_DNA.
DR   EMBL; LT898181; SNQ25991.1; -; Genomic_DNA.
DR   EMBL; LS398203; SPQ44332.1; -; Genomic_DNA.
DR   UniGene; Hs.181244; -.
DR   UniGene; Hs.713441; -.
DR   SMR; B0UXQ0; -.
DR   MaxQB; B0UXQ0; -.
DR   Ensembl; ENST00000550728; ENSP00000450169; ENSG00000231834.
DR   UCSC; uc011gqx.2; human.
DR   HGNC; HGNC:4931; HLA-A.
DR   HOVERGEN; HBG016709; -.
DR   ChiTaRS; HLA-A; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00447792};
KW   Immunity {ECO:0000256|SAAS:SAAS00446101};
KW   Membrane {ECO:0000256|SAAS:SAAS00447790, ECO:0000256|SAM:Phobius};
KW   MHC I {ECO:0000256|SAAS:SAAS00446101};
KW   Proteomics identification {ECO:0000213|EPD:B0UXQ0,
KW   ECO:0000213|MaxQB:B0UXQ0, ECO:0000213|PeptideAtlas:B0UXQ0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00447790,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00447790,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    365       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015087008.
FT   TRANSMEM    306    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      209    295       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   365 AA;  40841 MW;  4276F0222DE71589 CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ
     MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//