ID   B0L652_HUMAN            Unreviewed;       375 AA.
AC   B0L652;
DT   18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT   18-MAR-2008, sequence version 1.
DT   13-FEB-2019, entry version 62.
DE   SubName: Full=KIR2DL5 {ECO:0000313|EMBL:AFV74773.1};
DE   SubName: Full=KIR2DL5A {ECO:0000313|EMBL:ABM92655.1};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DL5A {ECO:0000313|Ensembl:ENSP00000480340};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DL5B {ECO:0000313|Ensembl:ENSP00000490994};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 3DS1 {ECO:0000313|Ensembl:ENSP00000491988};
DE   SubName: Full=Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 5 {ECO:0000313|EMBL:AJI81007.1};
GN   Name=KIR2DL5B {ECO:0000313|Ensembl:ENSP00000490994};
GN   Synonyms=KIR2DL5 {ECO:0000313|EMBL:AFV74773.1},
GN   KIR2DL5A {ECO:0000313|EMBL:ABM92655.1,
GN   ECO:0000313|Ensembl:ENSP00000480340},
GN   KIR3DS1 {ECO:0000313|Ensembl:ENSP00000491988};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABM92655.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480340, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:ABM92655.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18461314; DOI=10.1007/s00251-008-0273-7;
RA   Mulrooney T.J., Hou L., Steiner N.K., Chen M., Belle I., Ng J.,
RA   Hurley C.K.;
RT   "Promoter variants of KIR2DL5 add to diversity and may impact gene
RT   expression.";
RL   Immunogenetics 60:287-294(2008).
RN   [3] {ECO:0000313|EMBL:AFV74773.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pyo C.-W., Wang R., Vu Q.C., Geraghty D.E.;
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AFV74773.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23394822; DOI=10.1186/1471-2164-14-89;
RA   Pyo C.W., Wang R., Vu Q., Cereb N., Yang S.Y., Duh F.M., Wolinsky S.,
RA   Martin M.P., Carrington M., Geraghty D.E.;
RT   "Recombinant structures expand and contract inter and intragenic
RT   diversification at the KIR locus.";
RL   BMC Genomics 14:89-89(2013).
RN   [5] {ECO:0000313|Ensembl:ENSP00000480340}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [6] {ECO:0000313|EMBL:ANJ04793.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA   Ranade S., Geraghty D.E., Maiers M.;
RT   "Full Haplotype Sequences of the Killer Immunoglobulin-like Receptor
RT   (KIR) Region in Several Diverse Diploid Individuals using Single
RT   Molecule, Real-Time Sequencing.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AJI81007.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA   Ranade S., Geraghty D.E., Maiers M.;
RT   "Full Haplotype Sequences of the Killer Immunoglobulin-like Receptor
RT   (KIR) Region in Several Diverse Diploid Individuals using Single
RT   Molecule, Real-Time Sequencing.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Ensembl:ENSP00000490994}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
RN   [9] {ECO:0000313|Ensembl:ENSP00000495002}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; GU182339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF379096; ABM92655.1; -; Genomic_DNA.
DR   EMBL; JX008031; AFV74773.1; -; Genomic_DNA.
DR   EMBL; KP420440; AJI81007.1; -; Genomic_DNA.
DR   EMBL; KU645196; ANJ04793.1; -; Genomic_DNA.
DR   UniGene; Hs.740906; -.
DR   SMR; B0L652; -.
DR   Ensembl; ENST00000617974; ENSP00000483518; ENSG00000276392.
DR   Ensembl; ENST00000620638; ENSP00000480340; ENSG00000276686.
DR   Ensembl; ENST00000621273; ENSP00000484057; ENSG00000278116.
DR   Ensembl; ENST00000621304; ENSP00000484937; ENSG00000276177.
DR   Ensembl; ENST00000638381; ENSP00000490994; ENSG00000284301.
DR   Ensembl; ENST00000639063; ENSP00000491988; ENSG00000283719.
DR   Ensembl; ENST00000642705; ENSP00000495002; ENSG00000284301.
DR   Ensembl; ENST00000644091; ENSP00000496718; ENSG00000283719.
DR   UCSC; uc032lud.1; human.
DR   HGNC; HGNC:16345; KIR2DL5A.
DR   HGNC; HGNC:16346; KIR2DL5B.
DR   HGNC; HGNC:6340; KIR3DS1.
DR   HOVERGEN; HBG074353; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AJI81007.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    375       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015086967.
FT   TRANSMEM    239    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    116       IG. {ECO:0000259|SMART:SM00409}.
FT   DOMAIN      129    216       IG. {ECO:0000259|SMART:SM00409}.
SQ   SEQUENCE   375 AA;  40709 MW;  3A0C554F26F3EE20 CRC64;
     MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL
     YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL
     FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVDGTFQADF
     PLGPATHGGT YTCFSSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH
     ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
     LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL
     SQNRVASSHV PAAGI
//