ID   UPK3L_HUMAN             Reviewed;         263 AA.
AC   B0FP48; T2F9S8;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   13-FEB-2019, entry version 82.
DE   RecName: Full=Uroplakin-3b-like protein 1 {ECO:0000312|HGNC:HGNC:37278};
DE   Flags: Precursor;
GN   Name=UPK3BL1 {ECO:0000312|HGNC:HGNC:37278}; Synonyms=UPLP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eye;
RA   Wistow G.;
RT   "Human uroplakin-like protein.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=24450554; DOI=10.1186/1471-2148-14-13;
RA   Desalle R., Chicote J.U., Sun T.T., Garcia-Espana A.;
RT   "Generation of divergent uroplakin tetraspanins and their partners
RT   during vertebrate evolution: identification of novel uroplakins.";
RL   BMC Evol. Biol. 14:13-13(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
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DR   EMBL; EU341824; ABY56115.1; -; mRNA.
DR   EMBL; KF150200; AGV74289.1; -; mRNA.
DR   EMBL; AC105052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS47675.1; -.
DR   RefSeq; NP_001107875.1; NM_001114403.2.
DR   RefSeq; XP_016868385.1; XM_017012896.1.
DR   UniGene; Hs.610255; -.
DR   ProteinModelPortal; B0FP48; -.
DR   BioGrid; 756078; 33.
DR   STRING; 9606.ENSP00000342938; -.
DR   TCDB; 8.A.90.2.3; the uroplakin 2/3 (upk2/3) family.
DR   GlyConnect; 1888; -.
DR   iPTMnet; B0FP48; -.
DR   PhosphoSitePlus; B0FP48; -.
DR   BioMuta; UPK3BL1; -.
DR   jPOST; B0FP48; -.
DR   PaxDb; B0FP48; -.
DR   PRIDE; B0FP48; -.
DR   ProteomicsDB; 2542; -.
DR   Ensembl; ENST00000340457; ENSP00000342938; ENSG00000267368.
DR   GeneID; 100134938; -.
DR   GeneID; 107983993; -.
DR   KEGG; hsa:100134938; -.
DR   CTD; 100134938; -.
DR   CTD; 107983993; -.
DR   EuPathDB; HostDB:ENSG00000267368.1; -.
DR   GeneCards; UPK3BL1; -.
DR   HGNC; HGNC:37278; UPK3BL1.
DR   HPA; HPA011403; -.
DR   neXtProt; NX_B0FP48; -.
DR   OpenTargets; ENSG00000267368; -.
DR   PharmGKB; PA165618441; -.
DR   eggNOG; ENOG410IW5D; Eukaryota.
DR   eggNOG; ENOG41123W4; LUCA.
DR   HOGENOM; HOG000293265; -.
DR   InParanoid; B0FP48; -.
DR   OMA; LLIYTCY; -.
DR   OrthoDB; 1269506at2759; -.
DR   PhylomeDB; B0FP48; -.
DR   TreeFam; TF336628; -.
DR   PRO; PR:B0FP48; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000267368; Expressed in 88 organ(s), highest expression level in lower esophagus mucosa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR024831; Uroplakin-3.
DR   InterPro; IPR024827; Uroplakin-3b-like_1/2.
DR   PANTHER; PTHR15446; PTHR15446; 1.
DR   PANTHER; PTHR15446:SF2; PTHR15446:SF2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     33       {ECO:0000255}.
FT   CHAIN        34    263       Uroplakin-3b-like protein 1.
FT                                /FTId=PRO_0000375087.
FT   TOPO_DOM     34    204       Extracellular. {ECO:0000255}.
FT   TRANSMEM    205    225       Helical. {ECO:0000255}.
FT   TOPO_DOM    226    263       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     51     51       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     76     76       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     91     91       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   263 AA;  28385 MW;  CBA7419B03F7A57E CRC64;
     MDNSWRLGPA IGLSAGQSQL LVSLLLLLTR VQPGTDVAAP EHISYVPQLS NDTLAGRLTL
     STFTLEQPLG QFSSHNISDL DTIWLVVALS NATQSFTAPR TNQDIPAPAN FSQRGYYLTL
     RANRVLYQTR GQLHVLRVGN DTHCQPTKIG CNHPLPGPGP YRVKFLVMND EGPVAETKWS
     SDTRLQQAQA LRAVPGPQSP GTVVIIAILS ILLAVLLTVL LAVLIYTCFN SCRSTSLSGP
     EEAGSVRRYT THLAFSTPAE GAS
//