ID   DB108_HUMAN             Reviewed;          73 AA.
AC   A8MXU0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Putative beta-defensin 108A;
DE   AltName: Full=Defensin, beta 108A {ECO:0000312|HGNC:HGNC:18089};
DE   AltName: Full=Defensin, beta 108C {ECO:0000312|HGNC:HGNC:30847};
DE   AltName: Full=Putative beta-defensin 108B pseudogene 1/2;
DE   Flags: Precursor;
GN   Name=DEFB108A {ECO:0000312|HGNC:HGNC:18089}; Synonyms=DEFB108P1;
GN   and
GN   Name=DEFB108C {ECO:0000312|HGNC:HGNC:30847}; Synonyms=DEFB108P2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
RX   PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA   Semple C.A.M., Rolfe M., Dorin J.R.;
RT   "Duplication and selection in the evolution of primate beta-defensin
RT   genes.";
RL   Genome Biol. 4:R31.1-R31.11(2003).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC130360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF540980; -; NOT_ANNOTATED_CDS; mRNA.
DR   UniGene; Hs.583890; -.
DR   ProteinModelPortal; A8MXU0; -.
DR   BioMuta; HGNC:18089; -.
DR   PRIDE; A8MXU0; -.
DR   ProteomicsDB; 2353; -.
DR   GeneCards; DEFB108A; -.
DR   GeneCards; DEFB108C; -.
DR   HGNC; HGNC:18089; DEFB108A.
DR   HGNC; HGNC:30847; DEFB108C.
DR   HPA; HPA042588; -.
DR   neXtProt; NX_A8MXU0; -.
DR   HOGENOM; HOG000112137; -.
DR   HOVERGEN; HBG081400; -.
DR   InParanoid; A8MXU0; -.
DR   PhylomeDB; A8MXU0; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   PRO; PR:A8MXU0; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR15001; PTHR15001; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   5: Uncertain;
KW   Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23     73       Putative beta-defensin 108A.
FT                                /FTId=PRO_0000341263.
FT   DISULFID     28     55       {ECO:0000250}.
FT   DISULFID     35     49       {ECO:0000250}.
FT   DISULFID     39     56       {ECO:0000250}.
SQ   SEQUENCE   73 AA;  8390 MW;  ED4C8C652A4C7FDA CRC64;
     MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL NSRPCCLPLG
     HQPRIESTTP KKD
//