ID   A8MXP8_HUMAN            Unreviewed;       216 AA.
AC   A8MXP8;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   16-JAN-2019, entry version 79.
DE   SubName: Full=Reticulocalbin-2 {ECO:0000313|Ensembl:ENSP00000378347};
GN   Name=RCN2 {ECO:0000313|Ensembl:ENSP00000378347};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378347, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000378347, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000378347}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC051643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MXP8; -.
DR   SMR; A8MXP8; -.
DR   EPD; A8MXP8; -.
DR   jPOST; A8MXP8; -.
DR   MaxQB; A8MXP8; -.
DR   PeptideAtlas; A8MXP8; -.
DR   PRIDE; A8MXP8; -.
DR   Ensembl; ENST00000394883; ENSP00000378347; ENSG00000117906.
DR   UCSC; uc059lxq.1; human.
DR   EuPathDB; HostDB:ENSG00000117906.13; -.
DR   HGNC; HGNC:9935; RCN2.
DR   OpenTargets; ENSG00000117906; -.
DR   eggNOG; KOG4223; Eukaryota.
DR   eggNOG; ENOG410XRVE; LUCA.
DR   GeneTree; ENSGT00940000153732; -.
DR   HOGENOM; HOG000230934; -.
DR   HOVERGEN; HBG002834; -.
DR   ChiTaRS; RCN2; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000117906; Expressed in 248 organ(s), highest expression level in caput epididymis.
DR   ExpressionAtlas; A8MXP8; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13202; EF-hand_5; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A8MXP8,
KW   ECO:0000213|MaxQB:A8MXP8, ECO:0000213|PeptideAtlas:A8MXP8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    216       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726832.
FT   DOMAIN       85    120       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      132    161       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      162    197       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND      98    109       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND     139    150       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND     175    186       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   216 AA;  24796 MW;  5FB9BD6717F10BFD CRC64;
     MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQLH LKDKKRFEKA
     NQDSGPGLSL EEFIAFEHPE EVDYMTEFVI QEALEEHDKN GDGFVSLEEF LGDYRWDPTA
     NEDPEWILVE KDRFVNDYDK DNDGRLDPQE LLPWVVPNNQ GIAQEEALHL IDEMDLNGDK
     KLSEEEILEN PDLFLTSEAT DYGRQLHDDY FYHDEL
//