ID VSTM5_HUMAN Reviewed; 200 AA. AC A8MXK1; DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot. DT 04-DEC-2007, sequence version 1. DT 16-JAN-2019, entry version 79. DE RecName: Full=V-set and transmembrane domain-containing protein 5; DE Flags: Precursor; GN Name=VSTM5; Synonyms=C11orf90; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., RA Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cell adhesion-like membrane protein of the central CC nervous system (CNS) which modulates both the position and CC complexity of central neurons by altering their membrane CC morphology and dynamics. Involved in the formation of neuronal CC dendrites and protrusions including dendritic filopodia. In CC synaptogenesis, regulates synapse formation by altering dendritic CC spine morphology and actin distribution. Promotes formation of CC unstable neuronal spines such as thin and branched types. CC Regulates neuronal morphogenesis and migration during cortical CC development in the brain. {ECO:0000250|UniProtKB:Q9D806}. CC -!- SUBUNIT: Can homooligomerize through cis interactions within the CC same cell membrane. {ECO:0000250|UniProtKB:Q9D806}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:Q9D806}; Single-pass type I membrane CC protein {ECO:0000305}. Cell projection, dendrite CC {ECO:0000250|UniProtKB:Q9D806}. Cell projection, axon CC {ECO:0000250|UniProtKB:Q9D806}. CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9D806}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AP001894; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471065; EAW66922.1; -; Genomic_DNA. DR CCDS; CCDS44709.1; -. DR RefSeq; NP_001138343.1; NM_001144871.1. DR UniGene; Hs.512252; -. DR ProteinModelPortal; A8MXK1; -. DR STRING; 9606.ENSP00000386607; -. DR iPTMnet; A8MXK1; -. DR PhosphoSitePlus; A8MXK1; -. DR BioMuta; VSTM5; -. DR PaxDb; A8MXK1; -. DR PRIDE; A8MXK1; -. DR ProteomicsDB; 2330; -. DR Ensembl; ENST00000409977; ENSP00000386607; ENSG00000214376. DR GeneID; 387804; -. DR KEGG; hsa:387804; -. DR UCSC; uc010ruc.2; human. DR CTD; 387804; -. DR EuPathDB; HostDB:ENSG00000214376.5; -. DR GeneCards; VSTM5; -. DR HGNC; HGNC:34443; VSTM5. DR HPA; HPA029525; -. DR HPA; HPA063591; -. DR neXtProt; NX_A8MXK1; -. DR OpenTargets; ENSG00000214376; -. DR PharmGKB; PA164716741; -. DR eggNOG; ENOG410IISJ; Eukaryota. DR eggNOG; ENOG410YMAB; LUCA. DR GeneTree; ENSGT00530000063550; -. DR InParanoid; A8MXK1; -. DR OMA; TIEWKYT; -. DR OrthoDB; 1260992at2759; -. DR PhylomeDB; A8MXK1; -. DR TreeFam; TF332950; -. DR GenomeRNAi; 387804; -. DR PRO; PR:A8MXK1; -. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000214376; Expressed in 77 organ(s), highest expression level in frontal cortex. DR ExpressionAtlas; A8MXK1; baseline and differential. DR GO; GO:0030424; C:axon; ISS:UniProtKB. DR GO; GO:0030425; C:dendrite; ISS:UniProtKB. DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0046847; P:filopodium assembly; ISS:UniProtKB. DR GO; GO:1904891; P:positive regulation of excitatory synapse assembly; ISS:UniProtKB. DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB. DR GO; GO:0021517; P:ventral spinal cord development; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR SMART; SM00409; IG; 1. DR SUPFAM; SSF48726; SSF48726; 1. PE 3: Inferred from homology; KW Cell membrane; Cell projection; Complete proteome; KW Developmental protein; Glycoprotein; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 28 {ECO:0000255}. FT CHAIN 29 200 V-set and transmembrane domain-containing FT protein 5. FT /FTId=PRO_0000340693. FT TOPO_DOM 29 147 Extracellular. {ECO:0000255}. FT TRANSMEM 148 168 Helical. {ECO:0000255}. FT TOPO_DOM 169 200 Cytoplasmic. {ECO:0000255}. FT DOMAIN 37 139 Ig-like C2-type. FT REGION 170 186 Important for CDC42-dependent filopodia FT induction. FT {ECO:0000250|UniProtKB:Q9D806}. FT CARBOHYD 102 102 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. SQ SEQUENCE 200 AA; 22377 MW; 8B9EAF98C276CC89 CRC64; MRPLPSGRRK TRGISLGLFA LCLAAARCLQ SQGVSLYIPQ ATINATVKED ILLSVEYSCH GVPTIEWTYS SNWGTQKIVE WKPGTQANIS QSHKDRVCTF DNGSIQLFSV GVRDSGYYVI TVTERLGSSQ FGTIVLHVSE ILYEDLHFVA VILAFLAAVA AVLISLMWVC NKCAYKFQRK RRHKLKESTT EEIELEDVEC //