ID   A8MXH5_HUMAN            Unreviewed;      1707 AA.
AC   A8MXH5;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 88.
DE   SubName: Full=Collagen alpha-6(IV) chain {ECO:0000313|Ensembl:ENSP00000378340};
GN   Name=COL4A6 {ECO:0000313|Ensembl:ENSP00000378340};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378340, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000378340, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000378340}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL031177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL034369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL109943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001274687.1; NM_001287758.1.
DR   UniGene; Hs.145586; -.
DR   ProteinModelPortal; A8MXH5; -.
DR   SMR; A8MXH5; -.
DR   PRIDE; A8MXH5; -.
DR   Ensembl; ENST00000394872; ENSP00000378340; ENSG00000197565.
DR   GeneID; 1288; -.
DR   UCSC; uc033eqm.2; human.
DR   CTD; 1288; -.
DR   EuPathDB; HostDB:ENSG00000197565.15; -.
DR   HGNC; HGNC:2208; COL4A6.
DR   OpenTargets; ENSG00000197565; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   eggNOG; ENOG410YAVF; LUCA.
DR   GeneTree; ENSGT00940000153991; -.
DR   HOGENOM; HOG000085652; -.
DR   HOVERGEN; HBG004933; -.
DR   OMA; PMMPVGQ; -.
DR   OrthoDB; 63831at2759; -.
DR   ChiTaRS; COL4A6; human.
DR   GenomeRNAi; 1288; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000197565; Expressed in 152 organ(s), highest expression level in esophagus.
DR   ExpressionAtlas; A8MXH5; baseline and differential.
DR   GO; GO:0005587; C:collagen type IV trimer; IEA:Ensembl.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR   GO; GO:0038063; P:collagen-activated tyrosine kinase receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   Gene3D; 2.170.240.10; -; 1.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR001442; Collagen_IV_NC.
DR   InterPro; IPR036954; Collagen_IV_NC_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF01413; C4; 2.
DR   Pfam; PF01391; Collagen; 20.
DR   SMART; SM00111; C4; 2.
DR   SUPFAM; SSF56436; SSF56436; 2.
DR   PROSITE; PS51403; NC1_IV; 1.
PE   1: Evidence at protein level;
KW   Collagen {ECO:0000256|SAAS:SAAS00762088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01066595};
KW   Proteomics identification {ECO:0000213|MaxQB:A8MXH5,
KW   ECO:0000213|PeptideAtlas:A8MXH5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1707       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726085.
FT   DOMAIN     1483   1707       Collagen IV NC1.
FT                                {ECO:0000259|PROSITE:PS51403}.
SQ   SEQUENCE   1707 AA;  165468 MW;  BB7E0B93E8C6B1A4 CRC64;
     MHPGLWLLLV TLCLTEELAA AGEKSYGKPC GGQDCSGSCQ CFPEKGARGR PGPIGIQGPT
     GPQGFTGSTG LSGLKGERGF PGLLGPYGPK GDKGPMGVPG FLGINGIPGH PGQPGPRGPP
     GLDGCNGTQG AVGFPGPDGY PGLLGPPGLP GQKGSKGDPV LAPGSFKGMK GDPGLPGLDG
     ITGPQGAPGF PGAVGPAGPP GLQGPPGPPG PLGPDGNMGL GFQGEKGVKG DVGLPGPAGP
     PPSTGELEFM GFPKGKKGSK GEPGPKGFPG ISGPPGFPGL GTTGEKGEKG EKGIPGLPGP
     RGPMGSEGVQ GPPGQQGKKG TLGFPGLNGF QGIEGQKGDI GLPGPDVFID IDGAVISGNP
     GDPGVPGLPG LKGDEGIQGL RGPSGVPGLP ALSGVPGALG PQGFPGLKGD QGNPGRTTIG
     AAGLPGRDGL PGPPGPPGPP SPEFETETLH NKESGFPGLR GEQGPKGNLG LKGIKGDSGF
     CACDGGVPNT GPPGEPGPPG PWGLIGLPGL KGARGDRGSG GAQGPAGAPG LVGPLGPSGP
     KGKKGEPILS TIQGMPGDRG DSGSQGFRGV IGEPGKDGVP GLPGLPGLPG DGGQGFPGEK
     GLPGLPGEKG HPGPPGLPGN GLPGLPGPRG LPGDKGKDGL PGQQGLPGSK GDCCCREVGK
     GDLDTERGIT LPCIIPGSYG PSGFPGTPGF PGPKGSRGLP GTPGQPGSSG SKGEPGSPGL
     VHLPELPGFP GPRGEKGLPG FPGLPGKDGL PGMIGSPGLP GSKGATGDIF GAENGAPGEQ
     GLQGLTGHKG FLGDSGLPGL KGVHGKPGLL GPKGERGSPG TPGQVGQPGT PGSSGPYGIK
     GKSGLPGAPG FPGISGHPGK KGTRGKKGPP GSIVKKGLPG LKGLPGNPGL VGLKGSPGSP
     GVAGLPALSG PKGEKGSVGF VGFPGIPGLP GIPGTRGLKG IPGSTGKMGP SGRAGTPGEK
     GDRGNPGPVG IPSPRRPMSN LWLKGDKGSQ GSAGSNGFPG PRGDKGEAGR PGPPGLPGAP
     GLPGIIKGVS GKPGPPGFMG IRGLPGLKGS SGITGFPGMP GESGSQGIRG SPGLPGASGL
     PGLKGDNGQT VEISGSPGPK GQPGESGFKG TKGRDGLIGN IGFPGNKGED GKVGVSGDVG
     LPGAPGFPGV AGMRGEPGLP GSSGHQGAIG PLGSPGLIGP KGFPGFPGLH GLNGLPGTKG
     THGTPGPSIT GVPGPAGLPG PKGEKGYPGI GIGAPGKPGL RGQKGDRGFP GLQGPAGLPG
     APGISLPSLI AGQPGDPGRP GLDGERGRPG PAGPPGPPGP SSNQGDTGDP GFPGIPGPKG
     PKGDQGIPGF SGLPGELGLK GMRGEPGFMG TPGKVGPPGD PGFPGMKGKA GPRGSSGLQG
     DPGQTPTAEA VQVPPGPLGL PGIDGIPGLT GDPGAQGPVG LQGSKGLPGI PGKDGPSGLP
     GPPGALGDPG LPGLQGPPGF EGAPGQQGPF GMPGMPGQSM RVGYTLVKHS QSEQVPPCPI
     GMSQLWVGYS LLFVEGQEKA HNQDLGFAGS CLPRFSTMPF IYCNINEVCH YARRNDKSYW
     LSTTAPIPMM PVSQTQIPQY ISRCSVCEAP SQAIAVHSQD ITIPQCPLGW RSLWIGYSFL
     MHTAAGAEGG GQSLVSPGSC LEDFRATPFI ECSGARGTCH YFANKYSFWL TTVEERQQFG
     ELPVSETLKA GQLHTRVSRC QVCMKSL
//