ID   A8MXF1_HUMAN            Unreviewed;       171 AA.
AC   A8MXF1;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   13-FEB-2019, entry version 88.
DE   SubName: Full=Tyrosine-protein phosphatase non-receptor type 5 {ECO:0000313|Ensembl:ENSP00000379469};
GN   Name=PTPN5 {ECO:0000313|Ensembl:ENSP00000379469};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379469, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379469, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000379469}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   EMBL; AC103974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MXF1; -.
DR   jPOST; A8MXF1; -.
DR   PeptideAtlas; A8MXF1; -.
DR   PRIDE; A8MXF1; -.
DR   Ensembl; ENST00000396166; ENSP00000379469; ENSG00000110786.
DR   UCSC; uc057ztd.1; human.
DR   EuPathDB; HostDB:ENSG00000110786.17; -.
DR   HGNC; HGNC:9657; PTPN5.
DR   OpenTargets; ENSG00000110786; -.
DR   eggNOG; KOG0789; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000159916; -.
DR   HOGENOM; HOG000207861; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110786; Expressed in 119 organ(s), highest expression level in putamen.
DR   ExpressionAtlas; A8MXF1; baseline and differential.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR008356; Tyr_Pase_KIM-con.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR01778; KIMPTPASE.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031415};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A8MXF1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    171       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726916.
FT   DOMAIN        1    161       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN       75    152       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   REGION      102    108       Substrate binding.
FT                                {ECO:0000256|PIRSR:PIRSR608356-51}.
FT   ACT_SITE    102    102       Phosphocysteine intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR608356-50,
FT                                ECO:0000256|PROSITE-ProRule:PRU00160}.
FT   BINDING      67     67       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR608356-51}.
FT   BINDING     146    146       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR608356-51}.
SQ   SEQUENCE   171 AA;  19363 MW;  D50DD3F66B8B921A CRC64;
     MWPRWKGEGV PLSVFFLCSS SFHLISISGL VCELKEFTHT WGGPLSPRQS GTEERGLKHY
     WFTSWPDQKT PDRAPPLLHL VREVEEAAQQ EGPHCAPIIV HCSAGIGRTG CFIATSICCQ
     QLRQEGVVDI LKTTCQLRQD RGGMIQTCEQ YQFVHHVMSL YEKQLSHQSP E
//