ID   A8MXE0_HUMAN            Unreviewed;       167 AA.
AC   A8MXE0;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Prolyl 4-hydroxylase subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000378593};
DE   Flags: Fragment;
GN   Name=P4HA2 {ECO:0000313|Ensembl:ENSP00000378593};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378593, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000378593, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000378593}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC034220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC063976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MXE0; -.
DR   jPOST; A8MXE0; -.
DR   MaxQB; A8MXE0; -.
DR   PeptideAtlas; A8MXE0; -.
DR   PRIDE; A8MXE0; -.
DR   Ensembl; ENST00000395164; ENSP00000378593; ENSG00000072682.
DR   UCSC; uc063gtr.1; human.
DR   EuPathDB; HostDB:ENSG00000072682.18; -.
DR   HGNC; HGNC:8547; P4HA2.
DR   OpenTargets; ENSG00000072682; -.
DR   eggNOG; KOG1591; Eukaryota.
DR   eggNOG; ENOG410XS5J; LUCA.
DR   GeneTree; ENSGT00940000157695; -.
DR   HOGENOM; HOG000230465; -.
DR   HOVERGEN; HBG100075; -.
DR   ChiTaRS; P4HA2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000072682; Expressed in 211 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; A8MXE0; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR013547; Pro_4_hyd_alph_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF08336; P4Ha_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A8MXE0,
KW   ECO:0000213|MaxQB:A8MXE0, ECO:0000213|PeptideAtlas:A8MXE0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    167       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002724206.
FT   DOMAIN       26    156       P4Ha_N. {ECO:0000259|Pfam:PF08336}.
FT   NON_TER     167    167       {ECO:0000313|Ensembl:ENSP00000378593}.
SQ   SEQUENCE   167 AA;  18652 MW;  CEF0E56D861D0D30 CRC64;
     MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS
     WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR
     QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVD
//