ID K132L_HUMAN Reviewed; 1029 AA. AC A8MWY0; A4D1C9; B4DJV3; Q17RI6; Q96DP2; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAY-2008, sequence version 2. DT 13-FEB-2019, entry version 97. DE RecName: Full=UPF0577 protein KIAA1324-like; DE AltName: Full=Estrogen-induced gene 121-like protein; DE Short=hEIG121L; DE Flags: Precursor; GN Name=KIAA1324L; Synonyms=EIG121L; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Mesangial cell, and Thalamus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., RA Mural R.J., Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-1029 (ISOFORM 1). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP IDENTIFICATION. RX PubMed=17475571; DOI=10.1016/j.modgep.2007.03.004; RA Araki T., Kusakabe M., Nishida E.; RT "Expression of estrogen induced gene 121-like (EIG121L) during early RT Xenopus development."; RL Gene Expr. Patterns 7:666-671(2007). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1018, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=A8MWY0-1; Sequence=Displayed; CC Name=2; CC IsoId=A8MWY0-2; Sequence=VSP_033529, VSP_033530; CC Note=No experimental confirmation available.; CC Name=3; CC IsoId=A8MWY0-3; Sequence=VSP_043254, VSP_043255; CC Note=No experimental confirmation available.; CC -!- SIMILARITY: Belongs to the UPF0577 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAI17310.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=BAB71041.1; Type=Frameshift; Positions=719; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AK055902; BAB71041.1; ALT_FRAME; mRNA. DR EMBL; AK296250; BAG58965.1; -; mRNA. DR EMBL; AC000122; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC002081; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC004519; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH236949; EAL24181.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76969.1; -; Genomic_DNA. DR EMBL; BC117309; AAI17310.1; ALT_INIT; mRNA. DR CCDS; CCDS34677.2; -. [A8MWY0-3] DR CCDS; CCDS47632.1; -. [A8MWY0-1] DR RefSeq; NP_001136221.1; NM_001142749.2. [A8MWY0-1] DR RefSeq; NP_001278920.1; NM_001291991.1. [A8MWY0-2] DR RefSeq; NP_689961.3; NM_152748.3. [A8MWY0-3] DR RefSeq; XP_016867333.1; XM_017011844.1. [A8MWY0-3] DR UniGene; Hs.208093; -. DR ProteinModelPortal; A8MWY0; -. DR SMR; A8MWY0; -. DR BioGrid; 128789; 3. DR iPTMnet; A8MWY0; -. DR PhosphoSitePlus; A8MWY0; -. DR BioMuta; KIAA1324L; -. DR EPD; A8MWY0; -. DR jPOST; A8MWY0; -. DR MaxQB; A8MWY0; -. DR PaxDb; A8MWY0; -. DR PRIDE; A8MWY0; -. DR ProteomicsDB; 2277; -. DR ProteomicsDB; 2278; -. [A8MWY0-2] DR ProteomicsDB; 2279; -. [A8MWY0-3] DR DNASU; 222223; -. DR Ensembl; ENST00000416314; ENSP00000402390; ENSG00000164659. [A8MWY0-3] DR Ensembl; ENST00000450689; ENSP00000413445; ENSG00000164659. [A8MWY0-1] DR GeneID; 222223; -. DR KEGG; hsa:222223; -. DR UCSC; uc003uie.5; human. [A8MWY0-1] DR CTD; 222223; -. DR EuPathDB; HostDB:ENSG00000164659.14; -. DR GeneCards; KIAA1324L; -. DR HGNC; HGNC:21945; KIAA1324L. DR HPA; HPA044527; -. DR HPA; HPA076093; -. DR MIM; 614048; gene. DR neXtProt; NX_A8MWY0; -. DR OpenTargets; ENSG00000164659; -. DR PharmGKB; PA142671608; -. DR eggNOG; ENOG410IR7A; Eukaryota. DR eggNOG; ENOG410XVXU; LUCA. DR GeneTree; ENSGT00940000154983; -. DR HOGENOM; HOG000006645; -. DR HOVERGEN; HBG058349; -. DR InParanoid; A8MWY0; -. DR OMA; TECTFSC; -. DR OrthoDB; 192139at2759; -. DR PhylomeDB; A8MWY0; -. DR TreeFam; TF315906; -. DR ChiTaRS; KIAA1324L; human. DR GenomeRNAi; 222223; -. DR PRO; PR:A8MWY0; -. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000164659; Expressed in 187 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; A8MWY0; baseline and differential. DR Genevisible; A8MWY0; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR039181; EIG121-like. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like. DR PANTHER; PTHR22727; PTHR22727; 1. DR SMART; SM01411; Ephrin_rec_like; 4. DR SUPFAM; SSF57184; SSF57184; 2. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; KW Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 47 {ECO:0000255}. FT CHAIN 48 1029 UPF0577 protein KIAA1324-like. FT /FTId=PRO_0000333798. FT TOPO_DOM 48 929 Extracellular. {ECO:0000255}. FT TRANSMEM 930 950 Helical. {ECO:0000255}. FT TOPO_DOM 951 1029 Cytoplasmic. {ECO:0000255}. FT MOD_RES 1018 1018 Phosphoserine. FT {ECO:0000244|PubMed:23186163}. FT CARBOHYD 169 169 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 405 405 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 691 691 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 293 310 {ECO:0000250}. FT DISULFID 323 346 {ECO:0000250}. FT DISULFID 326 358 {ECO:0000250}. FT VAR_SEQ 1 240 Missing (in isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_033529. FT VAR_SEQ 1 167 Missing (in isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_043254. FT VAR_SEQ 168 169 NN -> MH (in isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_043255. FT VAR_SEQ 241 247 GEWGSHS -> MLEGNYQ (in isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_033530. FT VARIANT 539 539 N -> Y (in dbSNP:rs1029366). FT /FTId=VAR_043161. FT VARIANT 729 729 L -> V (in dbSNP:rs34412146). FT /FTId=VAR_043162. FT VARIANT 767 767 S -> R (in dbSNP:rs34577440). FT /FTId=VAR_043163. FT CONFLICT 678 678 H -> P (in Ref. 1; BAB71041). FT {ECO:0000305}. SQ SEQUENCE 1029 AA; 113842 MW; BF7E919BAB202DAF CRC64; MLFRARGPVR GRGWGRPAEA PRRGRSPPWS PAWICCWALA GCQAAWAGDL PSSSSRPLPP CQEKDYHFEY TECDSSGSRW RVAIPNSAVD CSGLPDPVRG KECTFSCASG EYLEMKNQVC SKCGEGTYSL GSGIKFDEWD ELPAGFSNIA TFMDTVVGPS DSRPDGCNNS SWIPRGNYIE SNRDDCTVSL IYAVHLKKSG YVFFEYQYVD NNIFFEFFIQ NDQCQEMDTT TDKWVKLTDN GEWGSHSVML KSGTNILYWR TTGILMGSKA VKPVLVKNIT IEGVAYTSEC FPCKPGTFSN KPGSFNCQVC PRNTYSEKGA KECIRCKDDS QFSEEGSSEC TERPPCTTKD YFQIHTPCDE EGKTQIMYKW IEPKICREDL TDAIRLPPSG EKKDCPPCNP GFYNNGSSSC HPCPPGTFSD GTKECRPCPA GTEPALGFEY KWWNVLPGNM KTSCFNVGNS KCDGMNGWEV AGDHIQSGAG GSDNDYLILN LHIPGFKPPT SMTGATGSEL GRITFVFETL CSADCVLYFM VDINRKSTNV VESWGGTKEK QAYTHIIFKN ATFTFTWAFQ RTNQGQDNRR FINDMVKIYS ITATNAVDGV ASSCRACALG SEQSGSSCVP CPPGHYIEKE TNQCKECPPD TYLSIHQVYG KEACIPCGPG SKNNQDHSVC YSDCFFYHEK ENQSLHYDFS NLSSVGSLMN GPSFTSKGTK YFHFFNISLC GHEGKKMALC TNNITDFTVK EIVAGSDDYT NLVGAFVCQS TIIPSESKGF RAALSSQSII LADTFIGVTV ETTLKNINIK EDMFPVPTSQ IPDVHFFYKS STATTSCING RSTAVKMRCN PTKSGAGVIS VPSKCPAGTC DGCTFYFLWE SAEACPLCTE HDFHEIEGAC KRGFQETLYV WNEPKWCIKG ISLPEKKLAT CETVDFWLKV GAGVGAFTAV LLVALTCYFW KKNQKLEYKY SKLVMTTNSK ECELPAADSC AIMEGEDNEE EVVYSNKQSL LGKLKSLATK EKEDHFESVQ LKTSRSPNI //