ID   F1712_HUMAN             Reviewed;         826 AA.
AC   A8MVW0; A8MQB4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   13-FEB-2019, entry version 84.
DE   RecName: Full=Protein FAM171A2;
DE   Flags: Precursor;
GN   Name=FAM171A2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66.
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19349973; DOI=10.1038/nbt.1532;
RA   Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA   Schiess R., Aebersold R., Watts J.D.;
RT   "Mass-spectrometric identification and relative quantification of N-
RT   linked cell surface glycoproteins.";
RL   Nat. Biotechnol. 27:378-386(2009).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-789, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM171 family. {ECO:0000305}.
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DR   EMBL; AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471178; EAW51598.1; -; Genomic_DNA.
DR   CCDS; CCDS45701.1; -.
DR   RefSeq; NP_940877.2; NM_198475.2.
DR   UniGene; Hs.154001; -.
DR   ProteinModelPortal; A8MVW0; -.
DR   BioGrid; 129748; 33.
DR   IntAct; A8MVW0; 1.
DR   STRING; 9606.ENSP00000293443; -.
DR   GlyConnect; 1658; -.
DR   iPTMnet; A8MVW0; -.
DR   PhosphoSitePlus; A8MVW0; -.
DR   SwissPalm; A8MVW0; -.
DR   BioMuta; FAM171A2; -.
DR   EPD; A8MVW0; -.
DR   jPOST; A8MVW0; -.
DR   MaxQB; A8MVW0; -.
DR   PaxDb; A8MVW0; -.
DR   PRIDE; A8MVW0; -.
DR   ProteomicsDB; 2208; -.
DR   Ensembl; ENST00000293443; ENSP00000293443; ENSG00000161682.
DR   GeneID; 284069; -.
DR   KEGG; hsa:284069; -.
DR   UCSC; uc002igs.3; human.
DR   CTD; 284069; -.
DR   EuPathDB; HostDB:ENSG00000161682.14; -.
DR   GeneCards; FAM171A2; -.
DR   H-InvDB; HIX0013883; -.
DR   HGNC; HGNC:30480; FAM171A2.
DR   HPA; HPA019770; -.
DR   neXtProt; NX_A8MVW0; -.
DR   OpenTargets; ENSG00000161682; -.
DR   PharmGKB; PA162387197; -.
DR   eggNOG; ENOG410IEC0; Eukaryota.
DR   eggNOG; ENOG410ZP57; LUCA.
DR   GeneTree; ENSGT00940000154190; -.
DR   HOGENOM; HOG000231925; -.
DR   HOVERGEN; HBG057508; -.
DR   InParanoid; A8MVW0; -.
DR   OMA; YWVAAMA; -.
DR   OrthoDB; 615320at2759; -.
DR   PhylomeDB; A8MVW0; -.
DR   TreeFam; TF331338; -.
DR   GenomeRNAi; 284069; -.
DR   PRO; PR:A8MVW0; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000161682; Expressed in 100 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; A8MVW0; baseline and differential.
DR   Genevisible; A8MVW0; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018890; Uncharacterised_FAM171.
DR   PANTHER; PTHR31626; PTHR31626; 1.
DR   Pfam; PF10577; UPF0560; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Glycoprotein; Membrane; Phosphoprotein;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     29       {ECO:0000255}.
FT   CHAIN        30    826       Protein FAM171A2.
FT                                /FTId=PRO_0000328771.
FT   TOPO_DOM     30    315       Extracellular. {ECO:0000255}.
FT   TRANSMEM    316    336       Helical. {ECO:0000255}.
FT   TOPO_DOM    337    826       Cytoplasmic. {ECO:0000255}.
FT   COMPBIAS    474    480       Poly-Pro.
FT   COMPBIAS    550    607       Gly-rich.
FT   COMPBIAS    715    722       Poly-Pro.
FT   MOD_RES     370    370       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:A2A699}.
FT   MOD_RES     372    372       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:A2A699}.
FT   MOD_RES     789    789       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   CARBOHYD     66     66       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:19349973}.
FT   CARBOHYD    201    201       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    221    221       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    265    265       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   826 AA;  87435 MW;  2845FC542702C3E0 CRC64;
     MPPASGPSVL ARLLPLLGLL LGSASRAPGK SPPEPPSPQE ILIKVQVYVS GELVPLARAS
     VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP GFLTNSVPWR VDKLPLYASV
     SLYLLPERPA TLILYEDLVH ILLGSPGARS QPLVQFQRRA ARLPVSSTYS QLWASLTPAS
     TQQEMRAFPA FLGTEASSSG NGSWLELMPL TAVSVHLLTG NGTEVPLSGP IHLSLPVPSE
     TRALTVGTSI PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTAGL
     VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ HRKLQLSGPS
     DGNKRDQATS MSQLHLICGG PLEPAPSGDP EAPPPGPLHS AFSSSRDLAS SRDDFFRTKP
     RSASRPAAEP SGARGGESAG LKGARSAEGP GGLEPGLEEH RRGPSGAAAF LHEPPSPPPP
     FDHYLGHKGA AEGKTPDFLL SQSVDQLARP PSLGQAGQLI FCGSIDHLKD NVYRNVMPTL
     VIPAHYVRLG GEAGAAGVGD EPAPPEGTAP GPARAFPQPD PQRPQMPGHS GPGGEGGGGG
     GEGWGAGRAA PVSGSVTIPV LFNESTMAQL NGELQALTEK KLLELGVKPH PRAWFVSLDG
     RSNSQVRHSY IDLQAGGGAR STDASLDSGV DVHEARPARR RPAREERERA PPAAPPPPPA
     PPRLALSEDT EPSSSESRTG LCSPEDNSLT PLLDEVAAPE GRAATVPRGR GRSRGDSSRS
     SASELRRDSL TSPEDELGAE VGDEAGDKKS PWQRREERPL MVFNVK
//