ID   A8MVE2_HUMAN            Unreviewed;       634 AA.
AC   A8MVE2;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 83.
DE   SubName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 1 {ECO:0000313|Ensembl:ENSP00000379610};
GN   Name=LILRB1 {ECO:0000313|Ensembl:ENSP00000379610};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379610, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379610, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000379610}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC245036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001265327.2; NM_001278398.2.
DR   UniGene; Hs.667388; -.
DR   ProteinModelPortal; A8MVE2; -.
DR   jPOST; A8MVE2; -.
DR   PeptideAtlas; A8MVE2; -.
DR   PRIDE; A8MVE2; -.
DR   Ensembl; ENST00000396317; ENSP00000379610; ENSG00000104972.
DR   GeneID; 10859; -.
DR   UCSC; uc061csd.1; human.
DR   CTD; 10859; -.
DR   EuPathDB; HostDB:ENSG00000104972.15; -.
DR   HGNC; HGNC:6605; LILRB1.
DR   OpenTargets; ENSG00000104972; -.
DR   eggNOG; ENOG410IKJD; Eukaryota.
DR   eggNOG; ENOG41116BR; LUCA.
DR   GeneTree; ENSGT00940000153160; -.
DR   HOGENOM; HOG000234395; -.
DR   HOVERGEN; HBG074353; -.
DR   OrthoDB; 1000446at2759; -.
DR   ChiTaRS; LILRB1; human.
DR   GenomeRNAi; 10859; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104972; Expressed in 179 organ(s), highest expression level in spleen.
DR   ExpressionAtlas; A8MVE2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A8MVE2,
KW   ECO:0000213|PeptideAtlas:A8MVE2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    634       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726826.
FT   TRANSMEM    443    467       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    115       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      313    409       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   634 AA;  69462 MW;  7917B74BD4FC8721 CRC64;
     MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL
     YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG
     AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA
     IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE
     TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA
     HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE
     GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS
     AGPEDQPLTP TGSDPQSGLG RHLGVVIGIL VAVILLLLLL LLLFLILRHR RQGKHWTSTQ
     RKADFQHPAG AVGPEPTDRG LQWRSSPAAD AQEENLYAAV KHTQPEDGVE MDTRSPHDED
     PQAVTYAEVK HSRPRREMAS PPSPLSGEFL DTKDRQAEED RQMDTEAAAS EAPQDVTYAQ
     LHSLTLRREA TEPPPSQEGP SPAVPSIYAT LAIH
//