ID   A8MVC2_HUMAN            Unreviewed;       494 AA.
AC   A8MVC2;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   05-DEC-2018, entry version 76.
DE   SubName: Full=Leucine-rich repeat LGI family member 4 {ECO:0000313|Ensembl:ENSP00000376059};
GN   Name=LGI4 {ECO:0000313|Ensembl:ENSP00000376059};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376059, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376059, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376059}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC020907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MVC2; -.
DR   PeptideAtlas; A8MVC2; -.
DR   PRIDE; A8MVC2; -.
DR   Ensembl; ENST00000392225; ENSP00000376059; ENSG00000153902.
DR   UCSC; uc060wyz.1; human.
DR   EuPathDB; HostDB:ENSG00000153902.13; -.
DR   HGNC; HGNC:18712; LGI4.
DR   OpenTargets; ENSG00000153902; -.
DR   eggNOG; ENOG410IJHU; Eukaryota.
DR   eggNOG; ENOG4111DWK; LUCA.
DR   GeneTree; ENSGT00940000162018; -.
DR   ChiTaRS; LGI4; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000153902; Expressed in 167 organ(s), highest expression level in tibial nerve.
DR   ExpressionAtlas; A8MVC2; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR009039; EAR.
DR   InterPro; IPR005492; EPTP.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF03736; EPTP; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00082; LRRCT; 1.
DR   PROSITE; PS50912; EAR; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
KW   Proteomics identification {ECO:0000213|MaxQB:A8MVC2,
KW   ECO:0000213|PeptideAtlas:A8MVC2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00597472};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    494       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726081.
FT   DOMAIN      158    207       LRRCT. {ECO:0000259|SMART:SM00082}.
FT   REPEAT      210    252       EAR. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00075}.
SQ   SEQUENCE   494 AA;  52848 MW;  33B086F89B6BC96D CRC64;
     MGGAGILLLL LAGAGVVVAW RPPKGKCPLR CSCSKDSALC EGSPDLPVSF SPTLLSLSLV
     RTGVTQLKAG SFLRIPSLHL LLFTSNSFSV IEDDAFAGLS HLQYLFIEDN EIGSISKNAL
     RGLRSLTHLS LANNHLETLP RFLFRGLDTL THVDLRGNPF QCDCRVLWLL QWMPTVNASV
     GTGACAGPAS LSHMQLHHLD PKTFKCRAIE LSWFQTVGES ALSVEPFSYQ GEPHIVLAQP
     FAGRCLILSW DYSLQRFRPE EELPGEPPPR PSACPAACLA GLTCLPTSPQ RPPWCPASHW
     CWARASSCWL PACGGAHSCG PGPVPACAWP QRRPWPRGGC CGPMTPSSCG WKGNPASWWP
     MPPRRAAPRC CAATGPAFTR TRACTPGTGT RTLRPWSWTA GPTCCWPRLP SGPCSSTGPV
     AASRDAQTSP RPRMSMPHAT SRLVGTCSCA SHATLGTPWS CAGTAPCFVC CSNFPRAVPT
     SSSHCSSPGT SWPS
//