ID   SERP3_HUMAN             Reviewed;         424 AA.
AC   A8MV23; B1V8P3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   13-FEB-2019, entry version 92.
DE   RecName: Full=Serpin E3;
DE   Flags: Precursor;
GN   Name=SERPINE3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Smolyar A.;
RT   "Polynucleotides encoding nexin-related serine protease inhibitor.";
RL   Patent number WO03046006, 05-JUN-2003.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Bentele C., Ragg H.;
RT   "Identification and characterization of a novel human serpin.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8MV23-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8MV23-2; Sequence=VSP_037586;
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AX772926; CAE06272.1; -; mRNA.
DR   EMBL; AM402969; CAL47031.1; -; mRNA.
DR   EMBL; AL137780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471075; EAX08871.1; -; Genomic_DNA.
DR   CCDS; CCDS53870.1; -. [A8MV23-1]
DR   RefSeq; NP_001094790.1; NM_001101320.1. [A8MV23-1]
DR   UniGene; Hs.685891; -.
DR   ProteinModelPortal; A8MV23; -.
DR   SMR; A8MV23; -.
DR   STRING; 9606.ENSP00000428316; -.
DR   MEROPS; I04.972; -.
DR   iPTMnet; A8MV23; -.
DR   PhosphoSitePlus; A8MV23; -.
DR   BioMuta; SERPINE3; -.
DR   PaxDb; A8MV23; -.
DR   PRIDE; A8MV23; -.
DR   ProteomicsDB; 2143; -.
DR   ProteomicsDB; 2144; -. [A8MV23-2]
DR   TopDownProteomics; A8MV23-1; -. [A8MV23-1]
DR   Ensembl; ENST00000400389; ENSP00000441468; ENSG00000253309. [A8MV23-2]
DR   Ensembl; ENST00000521255; ENSP00000428316; ENSG00000253309. [A8MV23-1]
DR   Ensembl; ENST00000524365; ENSP00000430755; ENSG00000253309. [A8MV23-2]
DR   GeneID; 647174; -.
DR   KEGG; hsa:647174; -.
DR   UCSC; uc001vfh.3; human. [A8MV23-1]
DR   CTD; 647174; -.
DR   EuPathDB; HostDB:ENSG00000253309.6; -.
DR   GeneCards; SERPINE3; -.
DR   HGNC; HGNC:24774; SERPINE3.
DR   HPA; HPA051904; -.
DR   HPA; HPA055804; -.
DR   neXtProt; NX_A8MV23; -.
DR   OpenTargets; ENSG00000253309; -.
DR   PharmGKB; PA164725650; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   eggNOG; COG4826; LUCA.
DR   GeneTree; ENSGT00940000160941; -.
DR   HOGENOM; HOG000154290; -.
DR   HOVERGEN; HBG108474; -.
DR   InParanoid; A8MV23; -.
DR   OMA; VSRWANS; -.
DR   OrthoDB; 1124079at2759; -.
DR   PhylomeDB; A8MV23; -.
DR   TreeFam; TF352620; -.
DR   GenomeRNAi; 647174; -.
DR   PRO; PR:A8MV23; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   Bgee; ENSG00000253309; Expressed in 80 organ(s), highest expression level in liver.
DR   ExpressionAtlas; A8MV23; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR031172; Serpin_E3.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF129; PTHR11461:SF129; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Glycoprotein; Polymorphism;
KW   Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    424       Serpin E3.
FT                                /FTId=PRO_0000340684.
FT   SITE        369    370       Reactive bond. {ECO:0000255}.
FT   CARBOHYD     46     46       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ     392    424       ITVFFDRIQIIYQCLSSNKGSFVHYPLKNKHSF -> FVFS
FT                                IGRVSNPLD (in isoform 2).
FT                                {ECO:0000303|Ref.2}.
FT                                /FTId=VSP_037586.
FT   VARIANT     143    143       D -> N (in dbSNP:rs17790811).
FT                                /FTId=VAR_044021.
SQ   SEQUENCE   424 AA;  46963 MW;  5B28DBB3317B4B1B CRC64;
     MPPFLITLFL FHSCCLRANG HLREGMTLLK TEFALHLYQS VAACRNETNF VISPAGVSLP
     LEILQFGAEG STGQQLADAL GYTVHDKRVK DFLHAVYATL PTSSQGTEME LACSLFVQVG
     TPLSPCFVEH VSWWANSSLE PADLSEPNST AIQTSEGASR ETAGGGPSEG PGGWPWEQVS
     AAFAQLVLVS TMSFQGTWRK RFSSTDTQIL PFTCAYGLVL QVPMMHQTTE VNYGQFQDTA
     GHQVGVLELP YLGSAVSLFL VLPRDKDTPL SHIEPHLTAS TIHLWTTSLR RARMDVFLPR
     FRIQNQFNLK SILNSWGVTD LFDPLKANLK GISGQDGFYV SEAIHKAKIE VLEEGTKASG
     ATALLLLKRS RIPIFKADRP FIYFLREPNT GITVFFDRIQ IIYQCLSSNK GSFVHYPLKN
     KHSF
//