ID   A8MUI5_HUMAN            Unreviewed;      1635 AA.
AC   A8MUI5;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 2.
DT   16-JAN-2019, entry version 69.
DE   SubName: Full=Leucine-rich repeat-containing protein 37A {ECO:0000313|Ensembl:ENSP00000377108};
GN   Name=LRRC37A {ECO:0000313|Ensembl:ENSP00000377108};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000377108, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000377108, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000377108}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC217777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MUI5; -.
DR   PeptideAtlas; A8MUI5; -.
DR   PRIDE; A8MUI5; -.
DR   Ensembl; ENST00000393465; ENSP00000377108; ENSG00000176681.
DR   UCSC; uc060gko.1; human.
DR   EuPathDB; HostDB:ENSG00000176681.14; -.
DR   HGNC; HGNC:29069; LRRC37A.
DR   OpenTargets; ENSG00000176681; -.
DR   eggNOG; ENOG410IJNR; Eukaryota.
DR   eggNOG; ENOG410YV94; LUCA.
DR   GeneTree; ENSGT00530000063282; -.
DR   HOGENOM; HOG000113269; -.
DR   HOVERGEN; HBG100009; -.
DR   OrthoDB; 181606at2759; -.
DR   ChiTaRS; LRRC37A; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000176681; Expressed in 85 organ(s), highest expression level in testis.
DR   ExpressionAtlas; A8MUI5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR015753; LRRC37.
DR   InterPro; IPR032754; LRRC37_N.
DR   InterPro; IPR029423; LRRC37AB_C.
DR   PANTHER; PTHR23045; PTHR23045; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF15779; LRRC37; 7.
DR   Pfam; PF14914; LRRC37AB_C; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A8MUI5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     37       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        38   1635       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726080.
FT   TRANSMEM   1582   1604       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      251    319       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      352    432       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      490    565       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      560    629       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      630    684       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      689    739       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      739    767       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN     1468   1612       LRRC37AB_C. {ECO:0000259|Pfam:PF14914}.
SQ   SEQUENCE   1635 AA;  180688 MW;  D8E35DD845D10C31 CRC64;
     MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPESW
     SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP
     LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL
     QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
     EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
     PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
     QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
     IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
     QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
     QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
     PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
     ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
     LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV
     QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
     LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
     LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
     HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL
     PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
     TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP
     FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
     AEEKRLTSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGTPSTSS
     PAKALPQVRD RSKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTTK
     VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSALSE
     HFIEKNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ
     TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
     LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS
     EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR
     DSEAPTEEEE SEALP
//