ID   A8MTV0_HUMAN            Unreviewed;       244 AA.
AC   A8MTV0;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase {ECO:0000313|Ensembl:ENSP00000379185};
GN   Name=PIGL {ECO:0000313|Ensembl:ENSP00000379185};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379185, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379185, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000379185}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016880843.1; XM_017025354.1.
DR   RefSeq; XP_016880844.1; XM_017025355.1.
DR   UniGene; Hs.499793; -.
DR   UniGene; Hs.625050; -.
DR   ProteinModelPortal; A8MTV0; -.
DR   SMR; A8MTV0; -.
DR   jPOST; A8MTV0; -.
DR   MaxQB; A8MTV0; -.
DR   PeptideAtlas; A8MTV0; -.
DR   Ensembl; ENST00000395844; ENSP00000379185; ENSG00000108474.
DR   GeneID; 9487; -.
DR   UCSC; uc060bri.1; human.
DR   CTD; 9487; -.
DR   EuPathDB; HostDB:ENSG00000108474.16; -.
DR   HGNC; HGNC:8966; PIGL.
DR   OpenTargets; ENSG00000108474; -.
DR   eggNOG; KOG3332; Eukaryota.
DR   eggNOG; COG2120; LUCA.
DR   GeneTree; ENSGT00390000018434; -.
DR   HOGENOM; HOG000176611; -.
DR   OrthoDB; 1454301at2759; -.
DR   ChiTaRS; PIGL; human.
DR   GenomeRNAi; 9487; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108474; Expressed in 186 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A8MTV0; baseline and differential.
DR   GO; GO:0000225; F:N-acetylglucosaminylphosphatidylinositol deacetylase activity; IEA:InterPro.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.10320; -; 1.
DR   InterPro; IPR003737; GlcNAc_PI_deacetylase-related.
DR   InterPro; IPR039516; GPI12.
DR   InterPro; IPR024078; LmbE-like_dom_sf.
DR   PANTHER; PTHR12993; PTHR12993; 1.
DR   PANTHER; PTHR12993:SF11; PTHR12993:SF11; 1.
DR   Pfam; PF02585; PIG-L; 1.
DR   SUPFAM; SSF102588; SSF102588; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A8MTV0,
KW   ECO:0000213|PeptideAtlas:A8MTV0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    244       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726824.
SQ   SEQUENCE   244 AA;  26790 MW;  5647FC6BFF095B4C CRC64;
     MEAMWLLCVA LAVLAWGFLW VWDSSERMKS REQGGRLGAE SRTLLVIAHP DDEAMFFAPT
     VLGLARLRHW VYLLCFSAGN YYNQGETRKK ELLQSCDVLG IPLSSVMIID NRDFPDDPGM
     QWDTEHVARV LLQHIEVNGI NLVVTFDAGG VSGHSNHIAL YAAVRVLCAH ASVCECAAQV
     HLPSGSALVS ASYAGCPLRA QQQRSGTGQE SHVLPPQPAP LVPPPLHYLL PVHENQLTEL
     PLKP
//