ID   HMSD_HUMAN              Reviewed;         139 AA.
AC   A8MTL9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   16-JAN-2019, entry version 89.
DE   RecName: Full=Serpin-like protein HMSD;
DE   AltName: Full=Minor histocompatibility protein HMSD;
DE   AltName: Full=Minor histocompatibility serpin domain-containing protein;
DE   Flags: Precursor;
GN   Name=HMSD;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND POLYMORPHISM.
RX   PubMed=17409267; DOI=10.1182/blood-2007-02-075911;
RA   Kawase T., Akatsuka Y., Torikai H., Morishima S., Oka A.,
RA   Tsujimura A., Miyazaki M., Tsujimura K., Miyamura K., Ogawa S.,
RA   Inoko H., Morishima Y., Kodera Y., Kuzushima K., Takahashi T.;
RT   "Alternative splicing due to an intronic SNP in HMSD generates a novel
RT   minor histocompatibility antigen.";
RL   Blood 110:1055-1063(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=8889548; DOI=10.1101/gr.6.9.791;
RA   Bonaldo M.F., Lennon G., Soares M.B.;
RT   "Normalization and subtraction: two approaches to facilitate gene
RT   discovery.";
RL   Genome Res. 6:791-806(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=HMSD;
CC         IsoId=A8MTL9-1; Sequence=Displayed;
CC       Name=2; Synonyms=HMSD-v;
CC         IsoId=P0C7T4-1; Sequence=External;
CC         Note=This alternative splicing event arises as a consequence of
CC         an intronic polymorphism.;
CC   -!- TISSUE SPECIFICITY: Highly expressed in dendritic cells and
CC       primary leukemia cells, especially those of myeloid lineage.
CC       {ECO:0000269|PubMed:17409267}.
CC   -!- POLYMORPHISM: Minor histocompatibility antigen ACC-6 (mHA ACC-6)
CC       is encoded by HMSD-v which is an allelic variant of HMSD. HMSD-v
CC       results from an intronic single-nucleotide polymorphism located at
CC       position 5 of HMSD intron 2 leading to a G to A substitution. This
CC       variation in intron 2 induces skipping of exon 2 and frameshift,
CC       resulting in expression of ACC-6.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- CAUTION: Translation of HMSD-v form generating mHA ACC-6 is in a
CC       frame different from that resulting in HMSD non variant form
CC       expression. Thus, HMSD sequence described in this entry does not
CC       contain the mHA ACC-6 peptide. {ECO:0000305}.
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DR   EMBL; BM696260; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AW205887; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC009802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471096; EAW63164.1; -; Genomic_DNA.
DR   CCDS; CCDS42441.1; -. [A8MTL9-1]
DR   RefSeq; NP_001116838.1; NM_001123366.1. [A8MTL9-1]
DR   UniGene; Hs.368077; -.
DR   UniGene; Hs.721604; -.
DR   ProteinModelPortal; A8MTL9; -.
DR   SMR; A8MTL9; -.
DR   STRING; 9606.ENSP00000386207; -.
DR   iPTMnet; A8MTL9; -.
DR   PhosphoSitePlus; A8MTL9; -.
DR   BioMuta; HMSD; -.
DR   EPD; A8MTL9; -.
DR   PaxDb; A8MTL9; -.
DR   PRIDE; A8MTL9; -.
DR   ProteomicsDB; 2034; -.
DR   Ensembl; ENST00000408945; ENSP00000386207; ENSG00000221887. [A8MTL9-1]
DR   GeneID; 284293; -.
DR   KEGG; hsa:284293; -.
DR   UCSC; uc010dqj.4; human. [A8MTL9-1]
DR   CTD; 284293; -.
DR   DisGeNET; 284293; -.
DR   EuPathDB; HostDB:ENSG00000221887.5; -.
DR   GeneCards; HMSD; -.
DR   HGNC; HGNC:23037; HMSD.
DR   MIM; 612086; gene.
DR   neXtProt; NX_A8MTL9; -.
DR   OpenTargets; ENSG00000221887; -.
DR   PharmGKB; PA162391030; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   eggNOG; COG4826; LUCA.
DR   GeneTree; ENSGT00940000154519; -.
DR   HOGENOM; HOG000112922; -.
DR   InParanoid; A8MTL9; -.
DR   OMA; KTKGENI; -.
DR   OrthoDB; 1124079at2759; -.
DR   PhylomeDB; A8MTL9; -.
DR   GenomeRNAi; 284293; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000221887; Expressed in 77 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; A8MTL9; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0002253; P:activation of immune response; IDA:UniProtKB.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Glycoprotein;
KW   Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    139       Serpin-like protein HMSD.
FT                                /FTId=PRO_0000343868.
FT   CARBOHYD     50     50       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   139 AA;  15355 MW;  9CFB7D6C86F2C6CC CRC64;
     MSISSALAMV FMGAKGNTAA QMSQALCFSK IGGEDGDIHR GFQSLLVAIN RTDTEYVLRT
     ANGLFGEKSY DFLTGFTDSC GKFYQATIKQ LDFVNDTEKS TTRVNSWVAD KTKGENILLF
     YFDNILNSFI VSSLQNCQI
//