ID   PRS47_HUMAN             Reviewed;         375 AA.
AC   A8MTI9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   16-JAN-2019, entry version 76.
DE   RecName: Full=Putative serine protease 47;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   Name=PRSS47;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AL136097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.742918; -.
DR   ProteinModelPortal; A8MTI9; -.
DR   SMR; A8MTI9; -.
DR   iPTMnet; A8MTI9; -.
DR   PhosphoSitePlus; A8MTI9; -.
DR   BioMuta; HGNC:37326; -.
DR   PRIDE; A8MTI9; -.
DR   ProteomicsDB; 2026; -.
DR   TopDownProteomics; A8MTI9; -.
DR   GeneCards; PRSS47; -.
DR   HGNC; HGNC:37326; PRSS47.
DR   neXtProt; NX_A8MTI9; -.
DR   HOVERGEN; HBG108718; -.
DR   InParanoid; A8MTI9; -.
DR   PhylomeDB; A8MTI9; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
PE   5: Uncertain;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Secreted; Serine protease; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    375       Putative serine protease 47.
FT                                /FTId=PRO_0000343890.
FT   DOMAIN       81    323       Peptidase S1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00274}.
FT   ACT_SITE    121    121       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   ACT_SITE    172    172       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   ACT_SITE    275    275       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   CARBOHYD    183    183       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    203    203       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    106    122       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    206    281       {ECO:0000255|PROSITE-ProRule:PRU00274}.
SQ   SEQUENCE   375 AA;  41188 MW;  67B5E9B321D03DC0 CRC64;
     MGYCQGVSQV AVVLLMFPKE KEAFLALAQL LTSKNLPDTV DGQLPMGPHS RASQVAPETT
     SSKVDRGVST VCGKPKVVGK IYGGRDAAAG QWPWQASLLY WGSHLCGAVL IDSCWLVSTT
     HCFLNKSQAP KNYQVLLGNI QLYHQTQHTQ KMSVHRIITH PDFEKLHPFG SDIAMLQLHL
     PMNFTSYIVP VCLPSRDMQL PSNVSCWITG WGMLTEDHKR GPVHTAVPSR LQAVCCSGCR
     GQRVGSRVGR FRSMIVHSEG QLRSLMPGDF HLGDSGGPLV CYLPSAWVLV GLASWGLDCR
     HPAYPSIFTR VTYFINWIDE IMRLTPLSDP ALAPHTCSPP KPLRAAGLPG PCAALVLPQT
     WLLLPLTLRA PWQTL
//