ID   CEA18_HUMAN             Reviewed;         384 AA.
AC   A8MTB9; C9JN24;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 4.
DT   13-FEB-2019, entry version 85.
DE   RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 18;
DE   Flags: Precursor;
GN   Name=CEACAM18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC       {ECO:0000305}.
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DR   EMBL; AC020914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.653111; -.
DR   ProteinModelPortal; A8MTB9; -.
DR   STRING; 9606.ENSP00000402203; -.
DR   BioMuta; HGNC:31949; -.
DR   EPD; A8MTB9; -.
DR   jPOST; A8MTB9; -.
DR   PaxDb; A8MTB9; -.
DR   PRIDE; A8MTB9; -.
DR   ProteomicsDB; 2012; -.
DR   Ensembl; ENST00000396477; ENSP00000379738; ENSG00000213822.
DR   UCSC; uc061bxs.1; human.
DR   EuPathDB; HostDB:ENSG00000213822.6; -.
DR   GeneCards; CEACAM18; -.
DR   HGNC; HGNC:31949; CEACAM18.
DR   HPA; HPA059487; -.
DR   neXtProt; NX_A8MTB9; -.
DR   OpenTargets; ENSG00000213822; -.
DR   PharmGKB; PA142672132; -.
DR   eggNOG; ENOG410JB7I; Eukaryota.
DR   eggNOG; ENOG4111BYI; LUCA.
DR   GeneTree; ENSGT00940000154387; -.
DR   HOGENOM; HOG000111529; -.
DR   HOVERGEN; HBG107644; -.
DR   InParanoid; A8MTB9; -.
DR   OMA; SQVEMEC; -.
DR   TreeFam; TF336859; -.
DR   PRO; PR:A8MTB9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000213822; Expressed in 5 organ(s), highest expression level in small intestine Peyer's patch.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Polymorphism; Reference proteome; Signal.
FT   SIGNAL        1     30       {ECO:0000255}.
FT   CHAIN        31    384       Carcinoembryonic antigen-related cell
FT                                adhesion molecule 18.
FT                                /FTId=PRO_0000339378.
FT   DOMAIN      227    314       Ig-like C2-type.
FT   CARBOHYD    108    108       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    112    112       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    121    121       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    162    162       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    270    270       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    255    296       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   VARIANT     160    160       L -> H (in dbSNP:rs8106673).
FT                                /FTId=VAR_043976.
FT   VARIANT     161    161       T -> A (in dbSNP:rs12610545).
FT                                /FTId=VAR_043977.
SQ   SEQUENCE   384 AA;  43320 MW;  B7D3DDB65B282C3B CRC64;
     MDLSRPRWSL WRRVFLMASL LACGICQASG QIFITQTLGI KGYRTVVALD KVPEDVQEYS
     WYWGANDSAG NMIISHKPPS AQQPGPMYTG RERVNREGSL LIRPTALNDT GNYTVRVVAG
     NETQRATGWL EVLELGSNLG ISVNASSLVE NMDSVAADCL TNVTNITWYV NDVPTSSSDR
     MTISPDGKTL VILRVSRYDR TIQCMIESFP EIFQRSERIS LTVAYGPDYV LLRSNPDDFN
     GIVTAEIGSQ VEMECICYSF LDLKYHWIHN GSLLNFSDAK MNLSSLAWEQ MGRYRCTVEN
     PVTQLIMYMD VRIQAPHEDL TCCPQRFLHL RIHGDVPHHA DSAGWRLHLW SPDPCSDQPL
     LNQDKSGSMS VHPRPEDKTR RASR
//