ID   A8MT20_HUMAN            Unreviewed;       298 AA.
AC   A8MT20;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   05-DEC-2018, entry version 81.
DE   SubName: Full=Metabotropic glutamate receptor 5 {ECO:0000313|Ensembl:ENSP00000376972};
GN   Name=GRM5 {ECO:0000313|Ensembl:ENSP00000376972};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376972, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376972, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376972}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP006214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP006215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MT20; -.
DR   SMR; A8MT20; -.
DR   PeptideAtlas; A8MT20; -.
DR   PRIDE; A8MT20; -.
DR   Ensembl; ENST00000393294; ENSP00000376972; ENSG00000168959.
DR   UCSC; uc009yvn.3; human.
DR   EuPathDB; HostDB:ENSG00000168959.14; -.
DR   HGNC; HGNC:4597; GRM5.
DR   OpenTargets; ENSG00000168959; -.
DR   eggNOG; KOG1056; Eukaryota.
DR   eggNOG; ENOG410XR6W; LUCA.
DR   GeneTree; ENSGT00940000155069; -.
DR   HOGENOM; HOG000015247; -.
DR   ChiTaRS; GRM5; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000168959; Expressed in 113 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; A8MT20; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR000202; GPCR_3_mtglu_rcpt_5.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01055; MTABOTROPC5R.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00425515};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A8MT20};
KW   Receptor {ECO:0000256|SAAS:SAAS00138718};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00425515};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00425515}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    298       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002726911.
FT   DOMAIN       68    221       ANF_receptor. {ECO:0000259|Pfam:PF01094}.
SQ   SEQUENCE   298 AA;  33587 MW;  1A0E6B063D98CD1A CRC64;
     MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV
     REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS
     EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG SSSVAIQVQN LLQLFNIPQI AYSATSMDLS
     DKTLFKYFMR VVPSDAQQAR AMVDIVKRYN WTYVSAVHTE GRGTKKEEMR KRDQTLMLSF
     MRCVFLRFEE IRWNDSLVYD ALENENIQVL SLCFPSSAVI QINTFLSPIA LINRLNVT
//