ID   A8MT18_HUMAN            Unreviewed;       398 AA.
AC   A8MT18;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 3.
DT   16-JAN-2019, entry version 74.
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DL4 {ECO:0000313|Ensembl:ENSP00000379584};
DE   Flags: Fragment;
GN   Name=KIR2DL4 {ECO:0000313|Ensembl:ENSP00000379584};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379584, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379584, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000379584}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000491554}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000492061}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AC245128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP420439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP420444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KU842452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A8MT18; -.
DR   jPOST; A8MT18; -.
DR   PRIDE; A8MT18; -.
DR   Ensembl; ENST00000396289; ENSP00000379584; ENSG00000189013.
DR   Ensembl; ENST00000638428; ENSP00000492061; ENSG00000284013.
DR   Ensembl; ENST00000639569; ENSP00000491554; ENSG00000284365.
DR   Ensembl; ENST00000641000; ENSP00000492041; ENSG00000283961.
DR   UCSC; uc061ctj.1; human.
DR   EuPathDB; HostDB:ENSG00000189013.14; -.
DR   HGNC; HGNC:6332; KIR2DL4.
DR   OpenTargets; ENSG00000189013; -.
DR   GeneTree; ENSGT00940000153748; -.
DR   HOGENOM; HOG000234396; -.
DR   HOVERGEN; HBG074353; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000189013; Expressed in 51 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A8MT18; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A8MT18,
KW   ECO:0000213|PeptideAtlas:A8MT18};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    398       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015086665.
FT   TRANSMEM    243    261       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35    119       IG. {ECO:0000259|SMART:SM00409}.
FT   DOMAIN      130    217       IG. {ECO:0000259|SMART:SM00409}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000379584}.
SQ   SEQUENCE   398 AA;  43729 MW;  8E9DAC408B3EBCE4 CRC64;
     XMSPTVIILA CLGFFLDQSV WAHVGGQDKP FCSAWPSAVV PQGGHVTLRC HYRRGFNIFT
     LYKKDGVPVP ELYNRIFWNS FLISPVTPAH AGTYRCRGFH PHSPTEWSAP SNPLVIMVTG
     LYEKPSLTAR PGPTVRAGEN VTLSCSSQSS FDIYHLSREG EAHELRLPAV PSINGTFQAD
     FPLGPATHGE TYRCFGSFHG SPYEWSDPSD PLPVSVTGNP SSSWPSPTEP SFKTGIARHL
     HAVIRYSVAI ILFTILPFFL LHRWCSKKKV SLTKQRPENS GPCAEAGWEH ADAAVMNQEP
     AGHRTVNRED SDEQDPQEVT YAQLDHCIFT QRKITGPSQR SKRPSTDTSV CIELPNAEPR
     ALSPAHEHHS QALMGSSRET TALSQTQLAS SNVPAAGI
//