ID   A8MQ07_HUMAN            Unreviewed;       730 AA.
AC   A8MQ07;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 3.
DT   16-JAN-2019, entry version 102.
DE   SubName: Full=Rap guanine nucleotide exchange factor 5 {ECO:0000313|Ensembl:ENSP00000343656};
GN   Name=RAPGEF5 {ECO:0000313|Ensembl:ENSP00000343656};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000343656, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000343656, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000343656}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_036426.3; NM_012294.3.
DR   RefSeq; XP_005249973.1; XM_005249916.1.
DR   UniGene; Hs.174768; -.
DR   UniGene; Hs.713217; -.
DR   ProteinModelPortal; A8MQ07; -.
DR   iPTMnet; A8MQ07; -.
DR   EPD; A8MQ07; -.
DR   jPOST; A8MQ07; -.
DR   MaxQB; A8MQ07; -.
DR   PeptideAtlas; A8MQ07; -.
DR   PRIDE; A8MQ07; -.
DR   Ensembl; ENST00000344041; ENSP00000343656; ENSG00000136237.
DR   GeneID; 9771; -.
DR   KEGG; hsa:9771; -.
DR   UCSC; uc003svg.4; human.
DR   CTD; 9771; -.
DR   EuPathDB; HostDB:ENSG00000136237.18; -.
DR   HGNC; HGNC:16862; RAPGEF5.
DR   OpenTargets; ENSG00000136237; -.
DR   eggNOG; KOG2378; Eukaryota.
DR   eggNOG; ENOG410XPX9; LUCA.
DR   GeneTree; ENSGT00940000155137; -.
DR   HOGENOM; HOG000230545; -.
DR   HOVERGEN; HBG056985; -.
DR   KO; K08019; -.
DR   OMA; EEIFCRV; -.
DR   OrthoDB; 143470at2759; -.
DR   PhylomeDB; A8MQ07; -.
DR   TreeFam; TF313184; -.
DR   ChiTaRS; RAPGEF5; human.
DR   GenomeRNAi; 9771; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000136237; Expressed in 216 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A8MQ07; baseline and differential.
DR   Genevisible; A8MQ07; HS.
DR   GO; GO:0016604; C:nuclear body; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A8MQ07};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    730       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002724124.
FT   DOMAIN      218    351       N-terminal Ras-GEF.
FT                                {ECO:0000259|PROSITE:PS50212}.
FT   DOMAIN      495    729       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
SQ   SEQUENCE   730 AA;  84730 MW;  62F175B2DCD9A8C0 CRC64;
     MAIGVWQLLL DMGIMLSVDQ HLYFQDTYVF YQFSSDECSY LYCEFEREEE WQNGVKLLLQ
     LVPLIPARGG ICELSHQKIE DSEESSDEIL VRLTSAVQRE LAAVIALKAR KSAIEQDEEN
     NDKHVAVTEA ESVPDSQAGV MCKLQERDEI GRIELVQKLA KENYQFLQTD KKEQEKSEHQ
     DDEVTTVQVK EQDQSVLVLK KVQCCGPAPT AGSAESHWRY VVVSGTPEKI LEHLLNDLHL
     EEVQDKETET LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL
     VSQWIALYKD WLPEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL GMHRRHTVDE
     YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT EHSYVSVKAK VSSIAQEILK
     VVAEKIQYAE EDLALVAITF SGEKHELQPN DLVISKSLEA SGRIYVYRKD LADTLNPFAE
     NEESQQRSMR ILGMNTWDLA LELMNFDWSL FNSIHEQELI YFTFSRQGSG EHTANLSLLL
     QRCNEVQLWV ATEILLCSQL GKRVQLVKKF IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR
     LSQTWEKIPG KFKKLFSELE SLTDPSLNHK AYRDAFKKMK PPKIPFMPLL LKDVTFIHEG
     NKTFLDNLVN FEKLHMIADT VRTLRHCRTN QFGDLSPKEH QELKSYVNHL YVIDSQQALF
     ELSHRIEPRV
//