ID   GBRR3_HUMAN             Reviewed;         467 AA.
AC   A8MPY1; Q9UIV9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   13-FEB-2019, entry version 97.
DE   RecName: Full=Gamma-aminobutyric acid receptor subunit rho-3;
DE   AltName: Full=GABA(A) receptor subunit rho-3;
DE   AltName: Full=GABA(C) receptor;
DE   Flags: Precursor;
GN   Name=GABRR3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 369-467.
RX   PubMed=10542332; DOI=10.1016/S0167-4781(99)00167-0;
RA   Bailey M.E.S., Albrecht B.E., Johnson K.J., Darlison M.G.;
RT   "Genetic linkage and radiation hybrid mapping of the three human
RT   GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.";
RL   Biochim. Biophys. Acta 1447:307-312(1999).
CC   -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC       vertebrate brain, mediates neuronal inhibition by binding to the
CC       GABA/benzodiazepine receptor and opening an integral chloride
CC       channel. {ECO:0000250}.
CC   -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC       receptor chains: alpha, beta, gamma, delta, and rho. Forms a
CC       ternary complex with SQSTM1 and PRKCZ (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC       Cell membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC       GABRR3 sub-subfamily. {ECO:0000305}.
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DR   EMBL; AC026100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Y18994; CAB60835.1; -; Genomic_DNA.
DR   CCDS; CCDS54617.1; -.
DR   RefSeq; NP_001099050.1; NM_001105580.2.
DR   UniGene; Hs.534578; -.
DR   ProteinModelPortal; A8MPY1; -.
DR   SMR; A8MPY1; -.
DR   STRING; 9606.ENSP00000471569; -.
DR   BindingDB; A8MPY1; -.
DR   ChEMBL; CHEMBL2109242; -.
DR   DrugBank; DB00546; Adinazolam.
DR   DrugBank; DB01558; Bromazepam.
DR   DrugBank; DB01594; Cinolazepam.
DR   DrugBank; DB01559; Clotiazepam.
DR   DrugBank; DB00829; Diazepam.
DR   DrugBank; DB01215; Estazolam.
DR   DrugBank; DB01567; Fludiazepam.
DR   DrugBank; DB00690; Flurazepam.
DR   DrugBank; DB00801; Halazepam.
DR   DrugBank; DB00683; Midazolam.
DR   DrugBank; DB01595; Nitrazepam.
DR   DrugBank; DB00842; Oxazepam.
DR   DrugBank; DB01588; Prazepam.
DR   DrugBank; DB01589; Quazepam.
DR   DrugBank; DB00231; Temazepam.
DR   DrugBank; DB00897; Triazolam.
DR   iPTMnet; A8MPY1; -.
DR   PhosphoSitePlus; A8MPY1; -.
DR   BioMuta; GABRR3; -.
DR   PaxDb; A8MPY1; -.
DR   PRIDE; A8MPY1; -.
DR   ProteomicsDB; 1925; -.
DR   Ensembl; ENST00000472788; ENSP00000420790; ENSG00000183185.
DR   Ensembl; ENST00000621172; ENSP00000481321; ENSG00000183185.
DR   GeneID; 200959; -.
DR   KEGG; hsa:200959; -.
DR   UCSC; uc021xbo.2; human.
DR   CTD; 200959; -.
DR   DisGeNET; 200959; -.
DR   EuPathDB; HostDB:ENSG00000183185.9; -.
DR   GeneCards; GABRR3; -.
DR   HGNC; HGNC:17969; GABRR3.
DR   neXtProt; NX_A8MPY1; -.
DR   OpenTargets; ENSG00000183185; -.
DR   PharmGKB; PA134952133; -.
DR   eggNOG; KOG3643; Eukaryota.
DR   eggNOG; ENOG410XPWH; LUCA.
DR   GeneTree; ENSGT00940000159906; -.
DR   HOVERGEN; HBG051707; -.
DR   InParanoid; A8MPY1; -.
DR   KO; K05190; -.
DR   OMA; HDTTVEN; -.
DR   OrthoDB; 480926at2759; -.
DR   PhylomeDB; A8MPY1; -.
DR   Reactome; R-HSA-977442; GABA A (rho) receptor activation.
DR   ChiTaRS; GABRR3; human.
DR   GeneWiki; GABRR3; -.
DR   GenomeRNAi; 200959; -.
DR   PRO; PR:A8MPY1; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000183185; Expressed in 6 organ(s), highest expression level in right lobe of liver.
DR   Genevisible; A8MPY1; HS.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; NAS:UniProtKB.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; NAS:UniProtKB.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Chloride; Chloride channel;
KW   Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Postsynaptic cell membrane;
KW   Reference proteome; Signal; Synapse; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    467       Gamma-aminobutyric acid receptor subunit
FT                                rho-3.
FT                                /FTId=PRO_0000332189.
FT   TOPO_DOM     24    266       Extracellular. {ECO:0000255}.
FT   TRANSMEM    267    287       Helical. {ECO:0000255}.
FT   TOPO_DOM    288    299       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    300    320       Helical. {ECO:0000255}.
FT   TOPO_DOM    321    331       Extracellular. {ECO:0000255}.
FT   TRANSMEM    332    352       Helical. {ECO:0000255}.
FT   TOPO_DOM    353    446       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    447    467       Helical. {ECO:0000255}.
FT   REGION      347    448       Interaction with SQSTM1. {ECO:0000250}.
FT   CARBOHYD    220    220       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    184    198       {ECO:0000250}.
SQ   SEQUENCE   467 AA;  54272 MW;  A374DCA1CF6079C6 CRC64;
     MVLAFQLVSF TYIWIILKPN VCAASNIKMT HQRCSSSMKQ TCKQETRMKK DDSTKARPQK
     YEQLLHIEDN DFAMRPGFGG SPVPVGIDVH VESIDSISET NMDFTMTFYL RHYWKDERLS
     FPSTANKSMT FDHRLTRKIW VPDIFFVHSK RSFIHDTTME NIMLRVHPDG NVLLSLRITV
     SAMCFMDFSR FPLDTQNCSL ELESYAYNED DLMLYWKHGN KSLNTEEHMS LSQFFIEDFS
     ASSGLAFYSS TGWYNRLFIN FVLRRHVFFF VLQTYFPAIL MVMLSWVSFW IDRRAVPARV
     SLGITTVLTM STIITAVSAS MPQVSYLKAV DVYLWVSSLF VFLSVIEYAA VNYLTTVEER
     KQFKKTGKIS RMYNIDAVQA MAFDGCYHDS EIDMDQTSLS LNSEDFMRRK SICSPSTDSS
     RIKRRKSLGG HVGRIILENN HVIDTYSRIL FPIVYILFNL FYWGVYV
//