ID   CLM7_HUMAN              Reviewed;         201 AA.
AC   A8K4G0; Q1EG73; Q8IX40; Q8N6D1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   13-FEB-2019, entry version 90.
DE   RecName: Full=CMRF35-like molecule 7;
DE            Short=CLM-7;
DE   AltName: Full=CD300 antigen-like family member B;
DE   AltName: Full=CMRF35-A2;
DE   AltName: Full=Immune receptor expressed on myeloid cells 3;
DE            Short=IREM-3;
DE   AltName: Full=Leukocyte mono-Ig-like receptor 5;
DE   AltName: Full=Triggering receptor expressed on myeloid cells 5;
DE            Short=TREM-5;
DE   AltName: CD_antigen=CD300b;
DE   Flags: Precursor;
GN   Name=CD300LB; Synonyms=CD300B, CLM7, CMRF35A2, IREM3, LMIR5, TREM5;
GN   ORFNames=UNQ2530/PRO6029;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY,
RP   PHOSPHORYLATION AT TYR-188, MUTAGENESIS OF LYS-158 AND TYR-188, AND
RP   INTERACTION WITH TYROBP.
RX   PubMed=16920917; DOI=10.4049/jimmunol.177.5.2819;
RA   Martinez-Barriocanal A., Sayos J.;
RT   "Molecular and functional characterization of CD300b, a new activating
RT   immunoglobulin receptor able to transduce signals through two
RT   different pathways.";
RL   J. Immunol. 177:2819-2830(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Colonna M.;
RT   "Triggering receptor expressed on myeloid cells 5.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   IDENTIFICATION.
RX   PubMed=12483297; DOI=10.1007/s00439-002-0851-y;
RA   Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L.,
RA   Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.;
RT   "Novel immunoglobulin superfamily gene cluster, mapping to a region of
RT   human chromosome 17q25, linked to psoriasis susceptibility.";
RL   Hum. Genet. 112:34-41(2003).
RN   [9]
RP   PHOSPHORYLATION AT TYR-188, INTERACTION WITH TYROBP, AND FUNCTION.
RX   PubMed=17928527; DOI=10.1182/blood-2007-04-085787;
RA   Yamanishi Y., Kitaura J., Izawa K., Matsuoka T., Oki T., Lu Y.,
RA   Shibata F., Yamazaki S., Kumagai H., Nakajima H., Maeda-Yamamoto M.,
RA   Tybulewicz V.L.J., Takai T., Kitamura T.;
RT   "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential
RT   regulation of LMIR5/CLM-7 in mouse versus human cells.";
RL   Blood 111:688-698(2008).
CC   -!- FUNCTION: Acts as an activating immune receptor through its
CC       interaction with ITAM-bearing adapter TYROBP, and also
CC       independently by recruitment of GRB2.
CC       {ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527}.
CC   -!- SUBUNIT: Interacts with TYROBP, which enhances cell surface
CC       expression and activation properties. Interacts with GRB2 in the
CC       presence of FYN. {ECO:0000269|PubMed:16920917,
CC       ECO:0000269|PubMed:17928527}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
CC       type I membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in myeloid lineages.
CC       {ECO:0000269|PubMed:16920917}.
CC   -!- PTM: Phosphorylation on Tyr-188 by FYN is required for interaction
CC       with GRB2. {ECO:0000269|PubMed:16920917,
CC       ECO:0000269|PubMed:17928527}.
CC   -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH28091.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=BAF83614.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=EAW89170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR   EMBL; AY646929; AAV69612.1; -; mRNA.
DR   EMBL; AF427618; AAN86133.1; -; mRNA.
DR   EMBL; AY359025; AAQ89384.1; -; mRNA.
DR   EMBL; AK290925; BAF83614.1; ALT_INIT; mRNA.
DR   EMBL; AC079325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471099; EAW89170.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BC028091; AAH28091.1; ALT_INIT; mRNA.
DR   CCDS; CCDS11700.2; -.
DR   RefSeq; NP_777552.3; NM_174892.3.
DR   UniGene; Hs.313343; -.
DR   ProteinModelPortal; A8K4G0; -.
DR   SMR; A8K4G0; -.
DR   BioGrid; 125877; 3.
DR   STRING; 9606.ENSP00000376397; -.
DR   iPTMnet; A8K4G0; -.
DR   PhosphoSitePlus; A8K4G0; -.
DR   BioMuta; CD300LB; -.
DR   PaxDb; A8K4G0; -.
DR   PRIDE; A8K4G0; -.
DR   ProteomicsDB; 1861; -.
DR   DNASU; 124599; -.
DR   Ensembl; ENST00000392621; ENSP00000376397; ENSG00000178789.
DR   GeneID; 124599; -.
DR   KEGG; hsa:124599; -.
DR   UCSC; uc002jkx.4; human.
DR   CTD; 124599; -.
DR   DisGeNET; 124599; -.
DR   EuPathDB; HostDB:ENSG00000178789.8; -.
DR   GeneCards; CD300LB; -.
DR   H-InvDB; HIX0014146; -.
DR   HGNC; HGNC:30811; CD300LB.
DR   MIM; 610705; gene.
DR   neXtProt; NX_A8K4G0; -.
DR   OpenTargets; ENSG00000178789; -.
DR   PharmGKB; PA142672151; -.
DR   eggNOG; ENOG410JBZ0; Eukaryota.
DR   eggNOG; ENOG41114E0; LUCA.
DR   GeneTree; ENSGT00940000162729; -.
DR   HOGENOM; HOG000231065; -.
DR   HOVERGEN; HBG103081; -.
DR   InParanoid; A8K4G0; -.
DR   KO; K20395; -.
DR   OMA; IRTHYVL; -.
DR   OrthoDB; 1494510at2759; -.
DR   PhylomeDB; A8K4G0; -.
DR   TreeFam; TF334441; -.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-HSA-2172127; DAP12 interactions.
DR   ChiTaRS; CD300LB; human.
DR   GenomeRNAi; 124599; -.
DR   PRO; PR:A8K4G0; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000178789; Expressed in 81 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; A8K4G0; baseline and differential.
DR   Genevisible; A8K4G0; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Disulfide bond; Immunity;
KW   Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     17       {ECO:0000255}.
FT   CHAIN        18    201       CMRF35-like molecule 7.
FT                                /FTId=PRO_0000320130.
FT   TOPO_DOM     18    151       Extracellular. {ECO:0000255}.
FT   TRANSMEM    152    172       Helical. {ECO:0000255}.
FT   TOPO_DOM    173    201       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       18    120       Ig-like V-type.
FT   SITE        158    158       Interaction with TYROBP.
FT   MOD_RES     188    188       Phosphotyrosine; by FYN.
FT                                {ECO:0000269|PubMed:16920917,
FT                                ECO:0000269|PubMed:17928527}.
FT   DISULFID     36    104       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   MUTAGEN     158    158       K->L: Abolishes interaction with TYROBP,
FT                                and strongly reduces activation
FT                                properties.
FT                                {ECO:0000269|PubMed:16920917}.
FT   MUTAGEN     188    188       Y->F: No effect on interaction with
FT                                TYROBP, but strongly reduces activation
FT                                properties.
FT                                {ECO:0000269|PubMed:16920917}.
FT   CONFLICT    144    144       G -> R (in Ref. 1; AAV69612).
FT                                {ECO:0000305}.
SQ   SEQUENCE   201 AA;  22689 MW;  2B8027A488B97CAF CRC64;
     MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC RGVRWDTCKI
     LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD VYWCGIERRG PDLGTQVKVI
     VDPEGAASTT ASSPTNSNMA VFIGSHKRNH YMLLVFVKVP ILLILVTAIL WLKGSQRVPE
     EPGEQPIYMN FSEPLTKDMA T
//